| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T40 |
0-68 |
Sentence |
denotes |
Pro-inflammatory stimuli activate several regulatory cell processes. |
| T41 |
69-256 |
Sentence |
denotes |
The activation of IKK (IκB kinase) causes the cleavage of NF-kβ, associated with nuclear translocation for p50 and p65, while that of MAPK directs the phosphorylation of p38, ERK and JNK. |
| T42 |
257-483 |
Sentence |
denotes |
Also notable are the dimerization of STAT3 and the association of HIFα with HIFβ, all resulting in the activation of several transcription factors or direct stimulation of gene expression, targeting pro-inflammatory molecules. |
| T43 |
484-675 |
Sentence |
denotes |
However, an increased expression of antioxidant enzymes can be encountered due to decreased degradation of Nrf2 and its activation of ARE, post-nuclear translocation and association with Maf. |
| T44 |
676-1226 |
Sentence |
denotes |
The activation of all the inflammation-related pathways, along the cellular and metabolic disturbances that follow, contributes to the high occurrence of obesity and associated pathology (diabetes mellitus, metabolic syndrome, CVD, Alzheimer's disease, etc), especially under the influence of modern life factors (malnutrition, smoking, pollution, low physical activity) (De Lorenzo et al., 2016; Georgescu et al., 2014; Georgescu, 2014; Gustafson et al., 2007; Libby, 2012; Ungurianu et al., 2017, 2019a; Wang et al., 2004; Zanfirescu et al., 2019). |
| T45 |
1227-1419 |
Sentence |
denotes |
The obese state is characterized by low-grade systemic inflammation, with impaired synthesis of adipokines and activation of pro-inflammatory signalling pathways leading to insulin resistance. |
| T46 |
1420-1572 |
Sentence |
denotes |
Adipose tissue inflammation is one of the determining factors of obesity complications, impairing the adipocyte secretory function and hormonal balance. |
