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PMC:7335494 / 85923-96664 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T512 0-57 Sentence denotes 7.2 Anti-inflammatory potential of polyphenols in humans
T513 58-250 Sentence denotes The anti-inflammatory effects induced by polyphenols in human studies with dietary interventions and weight related outcomes are heterogeneous, as summarized from recent literature (Table 7 ).
T514 251-476 Sentence denotes Thus, in a clinical study with double-blind, randomized, cross-over design, the effect of a commercially available polyphenols rich extract was tested, the study including patients having more than two metabolic risk factors.
T515 477-633 Sentence denotes Results showed a reduction of MCP-1 and MIF, but not of other markers of CVD risk (CRP, IL-6, HDL, adiponectin and oxidized LDL) (Broekhuizen et al., 2011).
T516 634-798 Sentence denotes In a separate clinical study with cross-over design, overweight patients consumed a high-carbohydrate, moderate-fat meal supplemented with strawberry/placebo juice.
T517 799-1000 Sentence denotes The anthocyanin supplementation blunted the postprandial inflammatory response (reduced CRP level) induced by the high fat diet and reduced the postprandial insulin response (Edirisinghe et al., 2011).
T518 1001-1182 Sentence denotes Furthermore, a double-blind study focused on hypercholesterolemia subjects, receiving a purified anthocyanin mixture, resulted in a reduction of their CRP, sVCAM-1 and IL-1β levels.
T519 1183-1378 Sentence denotes Similar results were obtained for HepG2 and porcine iliac artery endothelial cells exposed to the same purified anthocyanin mixture (reduction of LPS-induced VCAM-1 secretion) (Zhu et al., 2013).
T520 1379-1459 Sentence denotes Patients with early atherosclerosis, received simple or EGCG-enriched olive oil.
T521 1460-1644 Sentence denotes Independent of EGCG addition, olive oil reduced inflammatory markers and endothelial dysfunction (sICAM, white blood cells, monocytes, lymphocytes and platelets) (Widmer et al., 2013).
T522 1645-1731 Sentence denotes Table 7 Clinical data regarding the efficacy of polyphenols on inflammatory phenomena.
T523 1732-1801 Sentence denotes Design Population Type of intervention Inflammatory outcome Reference
T524 1802-1917 Sentence denotes Randomised, double-blind, cross-over study 34 subjects with two or more metabolic risk factors 4-week intervention:
T525 1918-2036 Sentence denotes 500 mg polyphenols/day vs. placebo ↓MCP-1 and MIF, unchanged levels of HDL, adiponectin, CRP Broekhuizen et al. (2011)
T526 2037-2223 Sentence denotes Cross-over study 24 overweight adults high-carbohydrate, moderate-fat meal together with a strawberry beverage (SB) or placebo SB:↓ CRP and postprandial insulin Edirisinghe et al. (2011)
T527 2224-2304 Sentence denotes Randomised, double-blind 150 hypercholesterolemic subjects 24-week intervention:
T528 2305-2379 Sentence denotes 640 mg purified Anthocyanin/day ↓ CRP, sVCAM-1 and IL-1β Zhu et al. (2013)
T529 2380-2466 Sentence denotes Randomised, double-blind 52 patients with early atherosclerosis, 4-month intervention:
T530 2467-2608 Sentence denotes 30 mL olive oil or 30 ml of EGCG-supplemented olive oil ↓ sICAM, white blood cells, monocytes, lymphocytes and platelets Widmer et al. (2013)
T531 2609-2906 Sentence denotes Single-centre, randomised, two-arm, double-blinded, placebo-controlled study 36 pre-hypertension patients, randomized to control or treatment groups 6-week intervention: grape seed extract, 150 mgx2/day ↓BP (SBP, DBP)↑ fasting insulin and insulin sensitivityNo change of sICAM-1 Park et al. (2016)
T532 2907-3003 Sentence denotes Single blinded crossover trial 38 patients with untreated mild hypertension 8-week intervention:
T533 3004-3114 Sentence denotes 300 mL/day cold-pressed 100% chokeberry juice and 3 g/day chokeberry powder ↓IL-10 and TNF-α Loo et al. (2016)
T534 3115-3344 Sentence denotes Randomized, double-blind, placebo-controlled clinical trial 50 hyperlipidemic patients 4-week intervention: V. arctostaphylos fruit extract x2/day no effects on HDL and CRP↓ total cholesterol, LDL-C, TG, MDA Soltani et al. (2014)
T535 3345-3423 Sentence denotes Placebo controlled study 20 study subjects and 19 placebo 4-week intervention:
T536 3424-3579 Sentence denotes 361 mg polyphenols and 120 mg vitamin C x2/day No significant effects on apolipoproteins, adiponectin, CRP, ICAM-1, E-Selectin or t-PA Mullan et al. (2016)
T537 3580-3644 Sentence denotes Placebo controlled study 16 trained cyclists 7-day intervention:
T538 3645-3754 Sentence denotes 30 mL of Montmorency tart cherry concentrate x 2/day ↓lipid hydroperoxides, IL-6 and hsCRP Bell et al. (2014)
T539 3755-3848 Sentence denotes Double-blind crossover study 49 healthy male subjects with APOE genotype 8-week intervention:
T540 3849-4022 Sentence denotes 150 mg/day quercetin or placebo (3 phases, three-week washout periods) ↓ waist circumference and postprandial SBP, moderately increased levels of TNFα Pfeuffer et al. (2013)
T541 4023-4196 Sentence denotes Randomised, double-blind, placebo-controlled, cross-over trial 18 healthy volunteers One-tine administration of 51 mg of oleuropeine ↓of IL8 production Lockyer et al. (2015)
T542 4197-4585 Sentence denotes Cross-sectional study 1997 females Frequency questionnaires assessment of total intake of flavonoids Higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistanceHigher anthocyanin intake was also associated with lower CRP concentrationsHigher anthocyanin-rich intake was associated with lower insulin and inflammation Jennings et al. (2014)
T543 4586-4749 Sentence denotes Randomized, controlled dietary study 27 subjects with metabolic syndrome 400 g fresh bilberries/days vs. control diet ↓ CRP, IL-6, IL-12, Kolehmainen et al. (2012)
T544 4750-4825 Sentence denotes The effects of grape seed extract on pre-hypertension patients were tested.
T545 4826-5094 Sentence denotes Results of the study in question, showed a reduction of blood pressure (both systolic and diastolic), with improved fasting insulin and insulin sensitivity after 6 weeks of supplementation, but no significant change in sICAM-1 plasma concentration (Park et al., 2016).
T546 5095-5320 Sentence denotes Furthermore, in a single blinded crossover trial including patients with untreated mild hypertension, cold-pressed chokeberry juice and dried chokeberry powder induced a reduction of IL-10 and TNF-α levels (Loo et al., 2016).
T547 5321-5570 Sentence denotes On the other hand, there are studies that do not confirm the positive effects of natural compounds on inflammatory markers regarding cardiovascular risk, especially on CRP, even if they prove to yield other beneficial outcomes (for example, on LDL).
T548 5571-5895 Sentence denotes Thus, Soltani et al. examined the effects of a Vaccinium arctostaphylosfruit extract on hyperlipidemic adult patients and even if no significant effects were observed regarding HDL and CRP, a significant reduction of total cholesterol, LDL, triglycerides and malondialdehyde (MDA) levels was obtained (Soltani et al., 2014).
T549 5896-6118 Sentence denotes Furthermore, Mullan et al. showed that administering a vitamin C and polyphenol-rich beverage didn't induce a reduction of metabolic or inflammatory markers (apolipoproteins, CRP, ICAM-1, E-selectin) (Mullan et al., 2016).
T550 6119-6267 Sentence denotes Results regarding the effect of polyphenols on inflammation were obtained not only in metabolically impaired patients, but also in healthy subjects.
T551 6268-6462 Sentence denotes Thus, in a placebo-controlled study, the effect induced by Montmorency tart cherry concentrate on the inflammatory and redox status markers in subjects simulating road cycle racing was examined.
T552 6463-6747 Sentence denotes Trained cyclists received the concentrate or placebo for 7 days, after which their oxidative stress and inflammatory markers (IL-6 and CRP) were reduced, highlighting the ability of the tested extract to improve the stress response in physical exercise conditions (Bell et al., 2014).
T553 6748-6956 Sentence denotes Furthermore, in a study with crossover, double-blind design, 49 healthy males with APOE genotype received 150 mg/day quercetin or placebo for 8 weeks, in three phases, separated by three-week washout periods.
T554 6957-7138 Sentence denotes Quercetin administration led to a decrease of waist circumference and postprandial systolic blood pressure, as well as a moderately increased levels of TNFα (Pfeuffer et al., 2013).
T555 7139-7325 Sentence denotes In a separate study with cross-over, double-blind, randomized, placebo-controlled design including 18 healthy subjects, the effect of oleuropeine (51 mg) on a single occasion was tested.
T556 7326-7471 Sentence denotes Blood of the subjects was collected and cells were stimulated with LPS, showing a significant decrease of IL-8 production (Lockyer et al., 2015).
T557 7472-7695 Sentence denotes Flavonoid-rich products have also been discussed for their beneficial effect on insulin resistance-related metabolic complications possibly via the upregulation of genes involved in insulin sensitivity (Engin et al., 2018).
T558 7696-7998 Sentence denotes In a recent review, the beneficial effect of flavonoid-rich products in a cross-sectional study including 1997 females aged 18–76 years, the correlation between the total flavonoid intake as well as their subclasses (assessed from food questionnaires) and insulin resistance/inflammation was evaluated.
T559 7999-8170 Sentence denotes Results showed higher anthocyanin and flavone intake were associated with significantly lower peripheral insulin resistance and CRP concentrations (Jennings et al., 2014).
T560 8171-8439 Sentence denotes In a randomized controlled dietary study, results showed that consuming a high anthocyanins diet is associated with the reduction of CRP, IL-6, IL-12, and LPS concentrations indicating a positive effect on the long term cardiometabolic risk (Kolehmainen et al., 2012).
T561 8440-8636 Sentence denotes According to literature data, polyphenols blunt the inflammatory response in clinical setting, thus reducing the cardio-vascular risk factors for hypertensive, obese or diabetes mellitus patients.
T562 8637-8861 Sentence denotes Positive effects on inflammation and redox stress markers were also obtained in healthy subjects and, moreover in trained athletes, who seem to benefit from the metabolic point of view from receiving polyphenols supplements.
T563 8862-9025 Sentence denotes Just a small number of published studies investigated if n-3 PUFAs may interact with the polyphenols and if a combined diet may have an enhanced beneficial impact.
T564 9026-9205 Sentence denotes Until now only the beneficial effects on HDL-levels (as a “surrogate” for the anti-inflammatory effect) were identified (Ahn et al., 2020; Annuzzi et al., 2014; Bub et al., 2019).
T565 9206-9411 Sentence denotes In an 8-week randomized controlled dietary study on overweight patients, a combined diet of high polyphenols and marine PUFAs- diet showed beneficial, although non-additive effects on plasma triglycerides.
T566 9412-9539 Sentence denotes Also, the reduction in oxidative stress (measured by urinary 8-isoprostane) was observed, probably as an effect of polyphenols.
T567 9540-9778 Sentence denotes A negative interaction between PUFAs and polyphenols was observed for some variables (chylomicron cholesterol and apo B-48 in large VLDLs), which suggest a possible kinetic interaction between PUFAs and polyphenols (Annuzzi et al., 2014).
T568 9779-9989 Sentence denotes This kinetic finding is also in line with some preclinical data that suggested that dietary polyphenols interact with the metabolism of n-3 PUFAs and increase blood EPA and DHA level (Toufektsian et al., 2011).
T569 9990-10264 Sentence denotes Recently, in a three monocentric, parallel-arm, double-blind, randomised, dietary intervention trial, 250 mg DHA and 320 mg grape anthocyanins administered as bioactive-enriched foods, for 4 weeks, had positive effects on serum triglyceride or HDL levels (Bub et al., 2019).
T570 10265-10484 Sentence denotes These results are partially in line with a later cross-sectional analysis in the Korean population that suggested beneficial effects exhibited only in men by high amounts of proanthocyanidins or n-3 PUFAs on HDL levels.
T571 10485-10563 Sentence denotes In addition, n-3 PUFAs intake increased polyphenols uptake (Ahn et al., 2020).
T572 10564-10741 Sentence denotes In conclusion, large-scale cohort studies with a combined diet PUFAs + polyphenols are needed to confirm the limited available data and to investigate possible additive effects.