| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T493 |
0-180 |
Sentence |
denotes |
Experimental studies arguing the involvement of polyphenols in mitigating inflammation are either performed on cell line models, animal models or have direct clinical implications. |
| T494 |
181-573 |
Sentence |
denotes |
In a study exposing human endothelial cells to the effect of Negroamaro and Primitivo extracts or pure compounds - stilbenes (trans-resveratrol, trans-piceid), hydroxycinnamic acids (p-coumaric, caffeic, and caftaric acids) flavonols (kaempferol, quercetin, myricetin) – before stimulation with lipopolysaccharide (LPS), an inhibition in the expression of adhesion molecules was demonstrated. |
| T495 |
574-803 |
Sentence |
denotes |
The anti-inflammatory effect was sustained by a reduction of VCAM-1, ICAM-1, E-selectin, MCP-1 and macrophage colony-stimulating factor (M-CSF), ROS intracellular levels with a correlated attenuation of NF-κB and AP-1 activation. |
| T496 |
804-897 |
Sentence |
denotes |
Trans-resveratrol also significantly reduced the endothelial expression and release of M-CSF. |
| T497 |
898-1074 |
Sentence |
denotes |
All tested compounds reduced the adhesion of monocytes to stimulated endothelial cells, this being a key element in the development of atherosclerosis (Calabriso et al., 2016). |
| T498 |
1075-1306 |
Sentence |
denotes |
The treatment of CCD-18Co myofibroblasts cells with red wine extract reduced mRNA levels of ICAM-1, VCAM-1, NF-κB, and PECAM-1, induced by LPS the anti-inflammatory mechanism being dependent on miR-126 (Angel-Morales et al., 2012). |
