| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T35 |
0-188 |
Sentence |
denotes |
Another important inflammatory pathway involves STAT3, a cytoplasm protein that is phosphorylated by JAK 1, 2, and 3 (Janus-activated kinases), under the influence of inflammatory stimuli. |
| T36 |
189-356 |
Sentence |
denotes |
STAT3 reaches the nucleus and functions as a transcriptional factor, stimulating the synthesis of inflammatory mediators (Pandurangan et al., 2015; Sung et al., 2012). |
| T37 |
357-648 |
Sentence |
denotes |
The MAPK/ERK (mitogen-activated protein kinases) group, including stress activated protein-kinases p38, JNK (c-Jun N-terminal kinases) and ERK (extracellular signal-regulated kinases), is also involved in the inflammatory cascade as a response to a detrimental stimulus (Liang et al., 2016). |
| T38 |
649-1020 |
Sentence |
denotes |
Also, to the family of transcription factors we can comprise nuclear factor erythroid 2-related factor 2 (Nrf2), activator protein-1 (AP-1), nuclear factor of activated T cells (NFAT) or hypoxia-inducible factor-1α (HIF-1α), all being recognized for their role in stress response as well as in mediating inflammation (Panieri et al., 2020; Reuter et al., 2010) (Fig. 1 ). |
| T39 |
1021-1764 |
Sentence |
denotes |
Fig. 1 Regulation of cellular pathways under the influence of pro-inflammatory stimuli (Keap1 – Kelch-like ECH-associated protein 1; Cul3 – Cullin 3; Nrf2 – Nuclear factor erythroid 2-related factor 2; IKK – IκB kinase; NF-κB – Nuclear factor kappa-light-chain-enhancer of activated B cells heterodimer, consisting of p50, p65 and IkBα proteins; STAT3 – Signal transducer and activator of transcription 3; ERK/MAPK – mitogen-activated protein kinases; JNK – c-Jun N-terminal kinases; MEK – Mitogen-activated protein kinases kinase; HIFα – Hypoxia-inducible factor α; HIFβ – Hypoxia-inducible factor β; AP1 – Activator protein 1, with its associated proteins cFOS - and cJUN; Maf – Transcription factor Maf; ARE – antioxidant response element). |
