LitCovid-sentences  

PMC:7326463 / 3296-5030 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T27 0-261 Sentence denotes Considering the very serious condition of the patient, and despite the fact that voriconazole is suggested as first-line treatment (alone or in combination) [3], caspofungin was added, assuming a potential synergistic effect with liposomal amphotericin B [4,5].
T28 262-385 Sentence denotes To test this hypothesis in vitro, we used the checkerboard method to assess combinations of amphotericin B and caspofungin.
T29 386-542 Sentence denotes The MIC of each drug alone and the combinations of the two were determined concomitantly on the same plate using a method adapted from the EUCAST procedure.
T30 543-775 Sentence denotes Interaction was determined by calculating the fractional inhibitory concentration index (FICI) as follows: FICI = (MIC amphotericin B in combination/MIC amphotericin B alone) + (MEC caspofungin in combination/MEC caspofungin alone).
T31 776-866 Sentence denotes Results showed no activity for caspofungin either alone or in combination (MEC > 32 mg/L).
T32 867-942 Sentence denotes The MIC value for amphotericin B was 1 mg/L either alone or in combination.
T33 943-1010 Sentence denotes The FICI value was equal to 2, which is indicative of indifference.
T34 1011-1108 Sentence denotes Moreover, as the patient's condition was beginning to improve, caspofungin was stopped on day 29.
T35 1109-1203 Sentence denotes Three other BALs performed on day 15, day 22 and day 27 still grew with Fusarium proliferatum.
T36 1204-1332 Sentence denotes Importantly, we noticed a gradual increase in the delay of culture positivity and a decrease in the number of colonies obtained.
T37 1333-1426 Sentence denotes Galactomannan testing became negative, all of which indicated a reduction of the fungal load.
T38 1427-1559 Sentence denotes The BALs performed on day 15 and day 27 also grew with a significant amount of bacteria, which led to specific antibiotic treatment.
T39 1560-1608 Sentence denotes The patient's general condition slowly improved.
T40 1609-1671 Sentence denotes He was extubated on day 30 then discharged to a post-ICU area.
T41 1672-1734 Sentence denotes Liposomal amphotericin B administration was stopped on day 35.