PMC:7326463 / 1237-3295 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T10 0-105 Sentence denotes A 57-year-old man was sent to our hospital after 7 days of fever and cough worsening over the last 24 hr.
T11 106-330 Sentence denotes On admission the patient presented signs of acute respiratory failure and was rapidly transferred to our intensive care unit (ICU) on March 26 (day 1) where he was intubated and placed under mechanical ventilation (Fig. 1 ).
T12 331-442 Sentence denotes The patient had no history of any acquired or inherited immunodeficiency and no underlying respiratory disease.
T13 443-625 Sentence denotes He was overweight (body mass index 30.6 kg/m2) with type 2 diabetes (blood glucose 11.6 mmol/L and glycosuria 1.4 mmol/L on admission), hypertension and a substituted hypothyroidism.
T14 626-698 Sentence denotes SARS-CoV-2 viral RNA was detected in a tracheal aspiration on admission.
T15 699-784 Sentence denotes The patient's condition worsened with a PaO2/FiO2 ratio <90 mmHg with a FiO2 of 100%.
T16 785-855 Sentence denotes A protected specimen brush sample performed on day 2 remained sterile.
T17 856-963 Sentence denotes While the patient's condition showed no improvement, a bronchoalveolar lavage (BAL) was performed on day 7.
T18 964-1073 Sentence denotes On day 9 this sample grew with 7 × 102/mL colony-forming unit (CFU) of mould while no bacteria were detected.
T19 1074-1235 Sentence denotes The same day, a second BAL was performed: atypical fungal hyphae were detected on microscopic examination, testing for galactomannan antigen was positive (index:
T20 1236-1286 Sentence denotes 1.7) and the sample grew with 103/mL CFU of mould.
T21 1287-1521 Sentence denotes The different cultures were identified as Fusarium proliferatum using mass spectrometry (Bruker Microflex with MSI database) and a liposomal amphotericin B-based therapy was started on day 12 (5 mg/kg/day for 2 days then 7 mg/kg/day).
T22 1522-1727 Sentence denotes Antifungal susceptibility testing determined using the gradient concentration strips method showed high minimal inhibitory concentrations (MICs) (>32 mg/L) for voriconazole, posaconazole and isavuconazole.
T23 1728-1772 Sentence denotes The MIC value for amphotericin B was 2 mg/L.
T24 1773-1887 Sentence denotes Fig. 1 Timeline for an immunocompetent patient who developed invasive pulmonary fusariosis during severe COVID-19.
T25 1888-1957 Sentence denotes Day 1 is the day the patient was admitted to the intensive care unit.
T26 1958-2058 Sentence denotes D, days; BAL, bronchoalveolar lavage; GM, galactomannan index determination; BDG, β-D-glucan dosage.