| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T54 |
0-19 |
Sentence |
denotes |
Sensing RNA Viruses |
| T55 |
20-91 |
Sentence |
denotes |
Innate immunity is essential in disease prevention and viral clearance. |
| T56 |
92-372 |
Sentence |
denotes |
Among the first responders to viral infections, tissue-resident macrophages and dendritic cells (DCs) (55) recognize evolutionarily conserved microbial structures termed pathogen-associated molecular patterns (PAMPs) via germline-encoded pattern recognition receptors (PRRs) (56). |
| T57 |
373-545 |
Sentence |
denotes |
In the context of respiratory RNA viruses, airway epithelial cells, that also express some PRRs (57), are often infected and have a major role in the first line of defense. |
| T58 |
546-723 |
Sentence |
denotes |
TLR3, TLR7, TLR8, MDA-5, and RIG-I are PRR expressed by immune and non-immune cells that are especially relevant in fighting respiratory RNA viruses, such as Coronaviruses (57). |
| T59 |
724-927 |
Sentence |
denotes |
Sensing through PRRs results in the transcription of genes involved in the inflammatory response, with type I interferons (IFNs) (IFN-α/β) production being a critical part of the antiviral response (58). |
| T60 |
928-1157 |
Sentence |
denotes |
Type I IFNs are produced by many immune and non-immune cells (55, 57, 59) and in addition to eliciting intrinsic antiviral responses (60), they are also essential to prime innate and adaptive lymphocytes, including NK cells (61). |
