| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T365 |
0-170 |
Sentence |
denotes |
Some viruses are known to induce a state of functional hyporesponsiveness in T cells that is essential for the productive establishment of chronic viral infections (190). |
| T366 |
171-311 |
Sentence |
denotes |
A vast body of literature has identified inhibitory checkpoint receptors, including CTLA4 and PD-1, as key regulators of this process (191). |
| T367 |
312-519 |
Sentence |
denotes |
Interestingly, cancer exploits similar mechanisms to escape the immune response, which provided the rationale for the introduction of antibodies targeting checkpoint receptors for cancer immunotherapy (192). |
| T368 |
520-763 |
Sentence |
denotes |
CTLA4 and PD-1/PD-L1 blockade have revolutionized cancer immunotherapy, and their success provides a strong rationale for the use of these drugs in COVID-19 patients, where emerging evidence suggests that the immune response is also subverted. |
| T369 |
764-932 |
Sentence |
denotes |
A clinical trial (NCT04268537) is currently assessing the efficacy of PD-1 blocking antibodies in severe COVID-19 patients within 48 h of reported respiratory distress. |
| T370 |
933-1121 |
Sentence |
denotes |
PD-1 has also been shown to play a role in regulating NK cell responses, in addition to modulating T cell functions (193–197), and has been reportedly increased in COVID-19 patients (129). |
