| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T156 |
0-301 |
Sentence |
denotes |
One of the main barriers in studying the role of NK cell activation in the early clearance of CoV infection in asymptomatic or mildly symptomatic patients is the fact that these individuals are rarely diagnosed in the clinic and therefore an opportunity to collect samples for research does not exist. |
| T157 |
302-518 |
Sentence |
denotes |
Thus, while there is currently no direct evidence to support a role for NK cells in the clearance of SARS-CoV-2, evidence showing that viral infection has a negative effect on the NK cell compartment is accumulating. |
| T158 |
519-1046 |
Sentence |
denotes |
Given the importance of NK cell activity in early viral clearance and late immunopathology, having a rapid and reliable test to predict NK cell function, such as NKVue™ (ATGen Canada/NKMax), whereby whole blood is stimulated by an NK cell-specific activating cytokine mix and activity is measured via IFN-γ production, might allow researchers to predict who will mount an adequate response with asymptomatic or minimally symptomatic viral clearance and who will need ICU admission, as has been shown with cancer patients (140). |
| T159 |
1047-1196 |
Sentence |
denotes |
Further research will be required into the innate immune response to CoV infection to more fully understand NK cell contributions to viral clearance. |
