| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T13 |
0-166 |
Sentence |
denotes |
Natural Killer (NK) cells are a key component of the innate immune system and are critical in the response to many viral infections in humans and animal models (1–3). |
| T14 |
167-377 |
Sentence |
denotes |
In addition to their beneficial antiviral role, NK cells have also been associated with immunopathology in infections such as respiratory syncytial virus (RSV) (4), influenza A virus (5–8), and hepatitis B (9). |
| T15 |
378-594 |
Sentence |
denotes |
Additionally, in the context of non-respiratory viral infections by HIV and HCV, NK cells appear to act as a rheostat by eliminating activated CD4+ and CD8+ T cells, thus preventing T cell-mediated autoimmunity (10). |
| T16 |
595-793 |
Sentence |
denotes |
The etiologic agent of the 2019 outbreak of pneumonia in Wuhan, China, was identified as belonging to the Coronaviridae family and named Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). |
| T17 |
794-950 |
Sentence |
denotes |
This virus causes the coronavirus Disease 2019 (COVID-19) which was declared a pandemic by the World Health Organization (WHO) on March 11th, 2020 (11, 12). |
| T18 |
951-1111 |
Sentence |
denotes |
With the paucity of information currently available, there is a lack of consensus on the role played by NK cells in the response to coronavirus (CoV) infection. |
| T19 |
1112-1239 |
Sentence |
denotes |
In this review, we will explore evidence for both the protective and pathological role that NK cells may play in CoV infection. |
| T20 |
1240-1376 |
Sentence |
denotes |
Based on this knowledge we will comment on immune modulating treatment options that are being developed for the current COVID-19 crisis. |
