LitCovid-sentences  

PMC:7323532 / 453-5879 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T6 0-208 Sentence denotes Patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) experience major lung damage due to viral replication and the ensuing cytokine storm and complex inflammatory processes (1).
T7 209-352 Sentence denotes The severe damage to lung tissue can lead to secondary infections within a median of 17 days after onset of coronavirus disease (COVID-19) (2).
T8 353-672 Sentence denotes Most immunocompetent patients who develop severe forms of COVID-19 have >1 underlying condition, such as chronic obstructive pulmonary disease, hypertension, diabetes, or chronic kidney disease (3), but none of these predisposing factors generally are associated with an increased risk for developing fungal infections.
T9 673-829 Sentence denotes Invasive aspergillosis is a well-described complication of severe influenza pneumonia (4,5), but many intensivists seem to overlook this superinfection (6).
T10 830-982 Sentence denotes A recent study reported a 19% incidence among 432 patients admitted to an intensive care unit (ICU) for influenza-related acute respiratory failure (4).
T11 983-1128 Sentence denotes Moreover, in a small autopsy series of patients who died in 2003 from SARS, 10% (2/20) had an invasive infection suggestive of aspergillosis (7).
T12 1129-1325 Sentence denotes As the medical community confronts the ongoing COVID-19 pandemic, determining whether patients infected with SARS-CoV-2 develop fungal complications, especially invasive aspergillosis, is crucial.
T13 1326-1479 Sentence denotes We report the case of a 74-year-old immunocompetent man with severe COVID-19–associated pneumonia who rapidly developed invasive pulmonary aspergillosis.
T14 1480-1557 Sentence denotes The patient had several underlying chronic diseases but no pulmonary disease.
T15 1558-1874 Sentence denotes Among his existing conditions were asymptomatic and untreated myelodysplastic syndrome, diagnosed on the basis of hypereosinophilia, with CD8+ T-cell lymphocytosis, a normal karyotype and low-risk International Prognostic Scoring System score; Hashimoto’s thyroiditis; hypertension; and benign prostatic hypertrophy.
T16 1875-2002 Sentence denotes On the morning of March 23, day 1, the patient fell out of bed, was unable to get up on his own, and called emergency services.
T17 2003-2099 Sentence denotes The patient described a 1-week history of fever and cough followed by onset of dyspnea that day.
T18 2100-2189 Sentence denotes Clinical examination showed signs of acute respiratory failure, tachypnea, and hypoxemia.
T19 2190-2339 Sentence denotes The patient was intubated, transported to the hospital, and transferred to the ICU, where he required mechanical ventilation and vasopressor support.
T20 2340-2440 Sentence denotes The same day, we took a protected distal aspiration before intravenous administration of cefotaxime.
T21 2441-2537 Sentence denotes SARS-CoV-2 viral RNA was detected in this sample by using 2 distinct reverse transcription PCRs.
T22 2538-2671 Sentence denotes The sample revealed 104/mL of Haemophilus influenzae, which was not found in a second protected distal aspiration performed on day 2.
T23 2672-2764 Sentence denotes The patient’s condition worsened, and he had a PaO2/FIO2 ratio <140 mm Hg with FIO2 of 100%.
T24 2765-2851 Sentence denotes We performed a tracheal aspirate on day 4 and sent samples to the mycology laboratory.
T25 2852-3022 Sentence denotes PCR for Aspergillus fumigatus was positive (430 copies/mL; 2.6 log), but galactomannan in the aspirate assay was negative, and culture on Sabouraud agar remained sterile.
T26 3023-3216 Sentence denotes Results of testing of a second tracheal aspiration performed on day 9 yielded branched septate hyphae suggestive of Aspergillus sp. under microscopic examination after silver staining (Figure).
T27 3217-3360 Sentence denotes A. fumigatus PCR was once again positive with a higher number of copies (3,600 copies/mL; 3.55 log); the galactomannan assay was not available.
T28 3361-3417 Sentence denotes The patient died that day of severe respiratory failure.
T29 3418-3510 Sentence denotes Culture on Sabouraud agar later grew a mold identified as A. fumigatus by mass spectrometry.
T30 3511-3584 Sentence denotes Of note, SARS-CoV-2 RNA still was detectable in the tracheal aspirations.
T31 3585-3757 Sentence denotes Results of serum analyses, including galactomannan index determination, β-D-glucan assay, and A. fumigatus PCR, were negative in serum samples collected on day 4 and day 8.
T32 3758-3900 Sentence denotes Figure Microscopic image of silver-stained tracheal aspirate from an immunocompetent patient critically ill with coronavirus disease, France.
T33 3901-3965 Sentence denotes Filaments suggestive of Aspergillus sp. are shown (black arrow).
T34 3966-3996 Sentence denotes Original magnification ×1,000.
T35 3997-4204 Sentence denotes This case fulfills the criteria of putative invasive aspergillosis according to the classification defined by Blot et al. for the diagnosis of invasive pulmonary aspergillosis in critically ill patients (8).
T36 4205-4332 Sentence denotes Because the patient’s illness took a rapid and fatal course, we did not have time to initiate appropriate antifungal treatment.
T37 4333-4455 Sentence denotes As previously reported, respiratory samples led to a diagnosis of aspergillosis, but blood samples lacked sensitivity (4).
T38 4456-4698 Sentence denotes Moreover, Aspergillus PCR contributed to the diagnosis, but the galactomannan was negative, consistent with what we previously reported about the lower sensitivity of the galactomannan compared with PCR and culture in respiratory samples (9).
T39 4699-4904 Sentence denotes A patient with a fatal SARS-CoV-2 infection recently was reported to have A. flavus on tracheal aspirates culture, but other evidence was missing, and diagnosis of aspergillosis was not substantiated (10).
T40 4905-5102 Sentence denotes Additional assessments are urgently needed to thoroughly investigate cases and promptly establish and define the cumulative incidence of invasive aspergillosis in ICU patients with severe COVID-19.
T41 5103-5245 Sentence denotes In conclusion, we report a case of invasive pulmonary aspergillosis in an immunocompetent patient during severe COVID-19–associated pneumonia.
T42 5246-5426 Sentence denotes As the COVID-19 outbreak continues to spread worldwide, other reports are needed to assess the occurrence and frequency of fungal complications during severe SARS-CoV-2 infections.