| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T3 |
0-270 |
Sentence |
denotes |
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds of thousands of people worldwide, highlighting an urgent need to develop antiviral therapies. |
| T4 |
271-467 |
Sentence |
denotes |
Here we present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins. |
| T5 |
468-643 |
Sentence |
denotes |
SARS-CoV-2 infection promoted casein kinase II (CK2) and p38 MAPK activation, production of diverse cytokines, and shutdown of mitotic kinases, resulting in cell cycle arrest. |
| T6 |
644-765 |
Sentence |
denotes |
Infection also stimulated a marked induction of CK2-containing filopodial protrusions possessing budding viral particles. |
| T7 |
766-895 |
Sentence |
denotes |
Eighty-seven drugs and compounds were identified by mapping global phosphorylation profiles to dysregulated kinases and pathways. |
| T8 |
896-1050 |
Sentence |
denotes |
We found pharmacologic inhibition of the p38, CK2, CDK, AXL, and PIKFYVE kinases to possess antiviral efficacy, representing potential COVID-19 therapies. |
