| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T283 |
0-313 |
Sentence |
denotes |
Comparing phosphoproteomics profiles of SARS-CoV-2-infected cells with a database of phosphorylation profiles collected at specific cell cycle stages, viral infection was most highly correlated with cells arrested at the S/G2 transition and was negatively correlated with profiles of cells in mitosis (Figure 6G). |
| T284 |
314-549 |
Sentence |
denotes |
We also observed SARS-CoV-2-dependent regulation of CDK2 T14/Y15 phosphorylation, initially increased in response to SARS-CoV-2 infection at 2 h, followed by a decrease over the remainder of the infection time course (Figure 6H, left). |
| T285 |
550-814 |
Sentence |
denotes |
CDK2 activity promotes transition from the G2 phase of the cell cycle into mitosis and is inhibited by phosphorylation at positions T14 and Y15 by kinases WEE1 and MYT1, preventing premature entry into mitosis (Parker and Piwnica-Worms 1992; Mueller et al., 1995). |
| T286 |
815-927 |
Sentence |
denotes |
CDK2 can also become phosphorylated when the cell cycle is arrested because of checkpoint failure or DNA damage. |
| T287 |
928-1184 |
Sentence |
denotes |
In addition, H2AX S140 phosphorylation (i.e., γ-H2AX), a hallmark of the DNA damage response, exhibited a profile similar to CDK2, suggesting that the DNA damage response may become activated early during infection (Rogakou et al., 1998; Figure 6H, right). |
