Id |
Subject |
Object |
Predicate |
Lexical cue |
T246 |
0-89 |
Sentence |
denotes |
Figure 6 SARS-CoV-2 Activates the p38/MAPK Signaling Pathway and Causes Cell Cycle Arrest |
T247 |
90-136 |
Sentence |
denotes |
(A) Diagram of the p38/MAPK signaling pathway. |
T248 |
137-202 |
Sentence |
denotes |
(B) Kinase activity analysis for kinases in the p38/MAPK pathway. |
T249 |
203-347 |
Sentence |
denotes |
(C) Western blot analysis of phosphorylated p38/MAPK signaling components in mock- and SARS-CoV-2-infected ACE2-A549 cells 24 h after infection. |
T250 |
348-456 |
Sentence |
denotes |
(D) Log2 fold change profiles of indicated p38/MAPK substrates during SARS-CoV-2 infection in Vero E6 cells. |
T251 |
457-662 |
Sentence |
denotes |
(E) Transcription factor activity analysis of SARS-CoV-2-infected A549, Calu-3, and NHBE cells, comparing p38/MAPK transcription factors with transcription factors not associated with the p38/MAPK pathway. |
T252 |
663-680 |
Sentence |
denotes |
Statistical test: |
T253 |
681-699 |
Sentence |
denotes |
Mann-Whitney test. |
T254 |
700-892 |
Sentence |
denotes |
(F) qRT-PCR analysis of the indicated mRNA from ACE2-A549 cells pre-treated with the p38 inhibitor SB203580 at the indicated concentrations for 1 h prior to infection with SARS-CoV-2 for 24 h. |
T255 |
893-910 |
Sentence |
denotes |
Statistical test: |
T256 |
911-928 |
Sentence |
denotes |
Student’s t test. |
T257 |
929-956 |
Sentence |
denotes |
See also Figures S4 and S5. |
T258 |
957-1171 |
Sentence |
denotes |
(G) Heatmap of Pearson’s correlation coefficients comparing SARS-CoV-2-infected Vero E6 phosphorylation profiles with profiles of cells with induced DNA damage and cells arrested at the indicated cell cycle stages. |
T259 |
1172-1301 |
Sentence |
denotes |
(H) Log2 fold change profiles of the indicated cell cycle and DNA damage substrates during SARS-CoV-2 infection in Vero E6 cells. |
T260 |
1302-1404 |
Sentence |
denotes |
(I) DNA content analysis of cells infected with SARS-CoV-2 for 24 h compared with mock-infected cells. |