| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T20 |
0-259 |
Sentence |
denotes |
To enter host cells, the SARS-CoV-2 spike (S) protein binds to an ACE2 receptor on the target cell and is subsequently primed by a serine protease, TMPRSS2, that cleaves the S protein and allows fusion of viral and lysosomal membranes (Hoffmann et al., 2020). |
| T21 |
260-494 |
Sentence |
denotes |
Following entry, viral genomic RNA is translated to produce the polyproteins ORF1a and ORF1ab, which are subsequently cleaved by viral proteases into non-structural proteins that form the viral replication/transcription complex (RTC). |
| T22 |
495-638 |
Sentence |
denotes |
Extensive remodeling of the host endoplasmic reticulum leads to formation of double-membrane vesicles, within which viral RNA synthesis occurs. |
| T23 |
639-837 |
Sentence |
denotes |
The viral RNA genome is replicated by transcription of the negative-strand genomic RNA template, whereas subgenomic mRNAs are transcribed and translated to produce structural and accessory proteins. |
| T24 |
838-1074 |
Sentence |
denotes |
Structural proteins and viral genomes assemble at the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) (de Haan and Rottier, 2005), followed by transport to the cell surface for release by exocytosis (Fehr and Perlman 2015). |
