| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T948 |
0-96 |
Sentence |
denotes |
Annotations for protein complexes were obtained from CORUM v3.0 database (Giurgiu et al., 2019). |
| T949 |
97-349 |
Sentence |
denotes |
Overall significance of changes of phosphosites of a protein complex was inferred from the log2 fold change of individual phosphosites of protein members of the complex using the same Z-test based approach described for estimation of kinase activities. |
| T950 |
350-473 |
Sentence |
denotes |
Among the 3512 complexes, 1070 complexes with phosphorylation changes obtained from 4 or more phosphosites were considered. |
| T951 |
474-599 |
Sentence |
denotes |
Of these, 67 complexes had significant phosphorylation change (-log10(p value) from Z-test > 2.5) in at least one time point. |
| T952 |
600-790 |
Sentence |
denotes |
In order to select non-redundant complexes, we first constructed a complex term tree based on distances (1-Jaccard Similarity Coefficients of shared genes) between the significant complexes. |
| T953 |
791-892 |
Sentence |
denotes |
The term tree was cut at a specific level (h = 0.99) to identify clusters of non-redundant complexes. |
| T954 |
893-944 |
Sentence |
denotes |
The largest complex was selected from each cluster. |
