PMC:7321036 / 108970-110051 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T932 0-61 Sentence denotes Estimation of kinase activities in the time-course experiment
T933 62-175 Sentence denotes Kinase activities were estimated using known kinase-substrate relationships in literature (Bachman et al., 2019).
T934 176-456 Sentence denotes The resource comprises of a comprehensive collection of phosphosite annotations of direct substrates of kinases obtained from six databases, PhosphoSitePlus, SIGNOR, HPRD, NCI-PID, Reactome, and the BEL Large Corpus, and using three text-mining tools, REACH, Sparser, and RLIMS-P.
T935 457-675 Sentence denotes Kinase activities were inferred as a -log10(p value) of Z-test from the comparison of fold changes in phosphosite measurements of the known substrates against the overall distribution of fold changes across the sample.
T936 676-830 Sentence denotes This statistical approach has been previously shown to perform well at estimating kinase activities (Hernandez-Armenta et al., 2017; Casado et al., 2013).
T937 831-902 Sentence denotes We collected substrate annotations for 400 kinases with available data.
T938 903-1081 Sentence denotes Kinase activities for kinases with 3 or more measured substrates were considered leaving us with 97 kinases with activity estimates in at least one or more infection time points.