Id |
Subject |
Object |
Predicate |
Lexical cue |
T932 |
0-61 |
Sentence |
denotes |
Estimation of kinase activities in the time-course experiment |
T933 |
62-175 |
Sentence |
denotes |
Kinase activities were estimated using known kinase-substrate relationships in literature (Bachman et al., 2019). |
T934 |
176-456 |
Sentence |
denotes |
The resource comprises of a comprehensive collection of phosphosite annotations of direct substrates of kinases obtained from six databases, PhosphoSitePlus, SIGNOR, HPRD, NCI-PID, Reactome, and the BEL Large Corpus, and using three text-mining tools, REACH, Sparser, and RLIMS-P. |
T935 |
457-675 |
Sentence |
denotes |
Kinase activities were inferred as a -log10(p value) of Z-test from the comparison of fold changes in phosphosite measurements of the known substrates against the overall distribution of fold changes across the sample. |
T936 |
676-830 |
Sentence |
denotes |
This statistical approach has been previously shown to perform well at estimating kinase activities (Hernandez-Armenta et al., 2017; Casado et al., 2013). |
T937 |
831-902 |
Sentence |
denotes |
We collected substrate annotations for 400 kinases with available data. |
T938 |
903-1081 |
Sentence |
denotes |
Kinase activities for kinases with 3 or more measured substrates were considered leaving us with 97 kinases with activity estimates in at least one or more infection time points. |