LitCovid-sentences  

PMC:7317273 / 18212-20180 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T310 0-215 Sentence denotes Despite years of success in MSC research, some of the challenges faced for successful transplantation therapy include heterogeneous treatment response, low number, and source-specific immunomodulatory response [22].
T311 216-358 Sentence denotes Interestingly, the reparative effects noticed in vivo indicate that clinical efficacy depends on the microenvironment of the transplants [23].
T312 359-466 Sentence denotes Therefore, the therapeutic capability of MSCs can be regulated and is an attractive area for investigation.
T313 467-647 Sentence denotes However, resting stage MSCs do not show the above potentials; it is only when they are exposed to a stimuli milieu, they demonstrate immunomodulatory or homing potentials [24, 25].
T314 648-793 Sentence denotes This indicates that the modulatory activity is not constitutively expressed by MSCs but is determined by the process of ‘priming’ to be obtained.
T315 794-971 Sentence denotes Therefore, the empowerment of MSCs by priming before a clinical application may be a potential solution to overcome the challenges that hinder the effectiveness of MSC outcomes.
T316 972-1121 Sentence denotes Priming, with inflammatory cytokines, is a process to modulate biological, biochemical or biophysical features that can influence cell fate [26, 27].
T317 1122-1261 Sentence denotes In recent years, several approaches have been proposed to improve the effectiveness, endurance and therapeutic efficiency of MSCs [28, 29].
T318 1262-1554 Sentence denotes Worth mentioning, the approaches utilizing MSCs, and especially the primed MSCs, could be vital for the success of cell therapy in lung complications, as the intravenously infused MSCs often get trapped in the lung; however, the retention time of MSCs within the lung is extremely short [30].
T319 1555-1649 Sentence denotes Though, the alteration in holding capacity of lung in a diseased scenario cannot be ruled out.
T320 1650-1968 Sentence denotes As primed MSCs could efficiently enhance retention [31], beside intensifying homing [17], and survival [32] in damaged lung, therefore, activation via priming could be a crucial mechanism for retention and engraftment of MSCs in a diseased lung, subsequently providing benefits to the lung through multiple mechanisms.