| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T208 |
0-61 |
Sentence |
denotes |
Correlation between BMPs and CEs Was Altered in Mild COVID-19 |
| T209 |
62-181 |
Sentence |
denotes |
Module II comprises BMP 38:5 (18:1/20:4) as the hub connected to numerous cholesteryl esters (CEs) by blue lines (+/−). |
| T210 |
182-336 |
Sentence |
denotes |
BMPs represent a class of structurally unique phospholipids enriched in MVBs implicated in cellular cholesterol homeostasis (Hullin-Matsuda et al., 2009). |
| T211 |
337-608 |
Sentence |
denotes |
BMPs also exhibit cell-type-specific compositions in their esterified fatty acyl chains, with pulmonary alveolar macrophages exhibiting distinct enrichment in n-6 fatty acids (i.e., linoleic acid 18:2 and arachidonic acid 20:4) (Cochran et al., 1987; Mason et al., 1972). |
| T212 |
609-889 |
Sentence |
denotes |
Among the various BMPs analyzed in our study, only BMP 38:5(18:1/20:4) and BMP 38:6(18:2/20:4) were specifically reduced in mild COVID-19 relative to healthy controls (Figure S4), suggesting that these reductions might be specific to pulmonary alveolar macrophages upon infection. |
| T213 |
890-1141 |
Sentence |
denotes |
BMPs were shown to influence cellular export of cholesterol by controlling cholesterol storage capacity of endosomes (Chevallier et al., 2008), which may explain the positive correlation between BMP 38:5(18:1/20:4) and several CEs in healthy controls. |
| T214 |
1142-1346 |
Sentence |
denotes |
The changes in correlations in mild COVID-19 (i.e., +/− and +/0) suggested that this process might be perturbed, in agreement with the observed reductions in circulating apo-A1 with COVID-19 (Figure S1C). |
| T215 |
1347-1686 |
Sentence |
denotes |
Of interest, we noticed that BMPs enriched in alveolar macrophages, i.e., BMP 38:5(18:1/20:4) (p = 0.0054) and BMP 38:6(18:2/20:4) (p = 0.0004), increased longitudinally with saturated CEs (CE 14:0, p = 0.0017; CE 16:0, p = 0.0092) from hospital admission to discharge in a small subset of patients who recovered from COVID-19 (Figure S2). |
