LitCovid-sentences  

PMC:7311890 / 21353-25227 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T146 0-98 Sentence denotes Plasma Lipidome Distinctly Associated with COVID-19 Resembles Exosomal Membrane Lipid Compositions
T147 99-262 Sentence denotes Lipids with overall false discovery rate (FDR) <0.05 were shortlisted and grouped according to major lipid classes for visual clarity in a forest plot (Figure 2 ).
T148 263-576 Sentence denotes We observed reductions in major classes of plasma glycerophospholipids including phosphatidic acids (PAs), phosphatidylinositols (PIs), and PCs, with accompanying increases in their corresponding lysophospholipids (i.e., LPAs, LPIs, and LPCs) that indicate enhanced phospholipase A2 activity in COVID-19 patients.
T149 577-725 Sentence denotes Cytosolic phospholipase A2α (cPLA2α) activation was reported to trigger pulmonary inflammation following pathogen infection (Bhowmick et al., 2017).
T150 726-813 Sentence denotes PUFA-PEs were the only diacyl forms of glycerophospholipids that increased in COVID-19.
T151 814-1035 Sentence denotes Changes in phospholipidome (i.e., reductions in PCs and PIs and increases in PEs) observed in COVID-19 corroborated a previous study on plasma lipid alterations in EVD fatalities compared to survivors (Kyle et al., 2019).
T152 1036-1369 Sentence denotes Among glycerophospholipids, PCs constitute the major membrane components of circulating lipoproteins (Cole et al., 2012), and PC-transfer protein (PC-TP) promotes cellular lipid efflux in nascent high-density lipoprotein (HDL) formation mediated by apolipoprotein A1 (apo-A1) (Baez et al., 2002), the major protein component of HDLs.
T153 1370-1519 Sentence denotes PI was found to exhibit selective enrichment in plasma HDL fractions and was not detected in plasma lipoprotein-free fractions (Dashti et al., 2011).
T154 1520-1740 Sentence denotes Changes in phospholipidome therefore suggested reductions in circulating HDLs as COVID-19 progresses, which was in agreement with the observed reductions in apo-A1 (p = 0.0687) as disease severity increases (Figure S1C).
T155 1741-1989 Sentence denotes As for neutral lipids, marked reductions in several DAGs, with concomitant increases in FFAs (e.g., FFA18:1 and FFA 18:2), were observed in mild and moderate COVID-19 (Figure 2), while TAGs were significantly reduced only in mild cases (Figure S4).
T156 1990-2165 Sentence denotes Increases in C18-FFAs and diminished TAGs were in agreement with previously reported circulating lipid changes associated with ARDS (Bursten et al., 1996; Maile et al., 2018).
T157 2166-2509 Sentence denotes In stark contrast to the glycerophospholipid and neutral lipid pathways, sphingolipid classes of SMs and GM3s, e.g., GM3 d18:1/16:0, GM3 d18:0/16:0, GM3 d18:1/25:0, and GM3 d18:0/25:0, displayed progressive increases with increasing severity (Figures 2 and S4), possibly reflecting the augmented secretion of these lipids into the circulation.
T158 2510-2754 Sentence denotes Of particular interest, lipidomes of exosomal membranes were previously shown to be specifically enriched in SMs (Stoorvogel et al., 2002) with diminished DAGs that cumulatively give rise to enhanced membrane rigidity (Laulagnier et al., 2004).
T159 2755-2890 Sentence denotes Exosomes from lymphocytes also exhibited cell-type-specific enrichments in GM3s (Wubbolts et al., 2003) and PSs (Brügger et al., 2006).
T160 2891-3142 Sentence denotes Thus, a gross overview of plasma lipidomic signatures distinctly associated with COVID-19, taking into account baseline cofounders, revealed a close resemblance to that of exosomal lipid compositions (i.e., enriched in SMs and GM3s with reduced DAGs).
T161 3143-3202 Sentence denotes Figure 2 Plasma Lipids Associated with Severity of COVID-19
T162 3203-3438 Sentence denotes Logistic regression model with covariates BMI, age, and sex was built with each lipid to search for significant variables that could predict disease severity of subjects (i.e., healthy control, and mild, moderate, and severe COVID-19).
T163 3439-3520 Sentence denotes Only lipids with false discovery rate (FDR) <0.05 were shortlisted and presented.
T164 3521-3671 Sentence denotes Forest plots illustrate the magnitude of odds ratios with indicator of significance of the estimate in the model; ∗∗∗p < 0.001, ∗∗p < 0.01, ∗p < 0.05.
T165 3672-3736 Sentence denotes For non-significant lipids, the estimates were plotted as zeros.
T166 3737-3854 Sentence denotes Lipids were broadly classified according to major classes of neutral lipids, glycerophospholipids, and sphingolipids.
T167 3855-3874 Sentence denotes See also Figure S4.