LitCovid-sentences  

PMC:7311890 / 10726-14507 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T65 0-113 Sentence denotes Blood Routine and Circulating Markers of Systemic Inflammation Indicated Dysregulated Immune Response in COVID-19
T66 114-324 Sentence denotes Demographic and laboratory findings of the 50 recruited COVID-19 patients (Tables 1 and S1) were in good agreement with published literature on clinical characteristics of COVID-19 in China (Guan et al., 2020).
T67 325-517 Sentence denotes Reductions in lymphocyte count (LC) (p < 0.0001) (Table S1), particularly in the numbers of T lymphocytes and CD4+ T lymphocytes (Figure S1A), were associated with increasing disease severity.
T68 518-796 Sentence denotes Our observations were aligned with previous findings on laboratory-confirmed COVID-19 cases in Wuhan for which particularly drastic reductions in CD4+ T cell counts indicative of dysregulated immune response were noted, especially in severe COVID-19 patients (Qin et al., 2020).
T69 797-1117 Sentence denotes Indices of systemic inflammation, including C-reactive protein (CRP) (p = 0.0003), interleukin-6 (IL-6) (p = 0.0958), erythrocyte sedimentation rate (ESR) (p = 0.0008), serum ferritin (SF) (p = 0.0001), and procalcitonin (p = 0.0171), exhibited progressive increases as disease severity increased (Figure S1B; Table S1).
T70 1118-1267 Sentence denotes We utilized a combination of targeted lipidomics (Lu et al., 2019) and untargeted metabolomics optimized in-house for screening human plasma samples.
T71 1268-1453 Sentence denotes Our untargeted metabolomics detected an initial pool of 1,552 metabolite peaks with coefficients of variations <20% across quality control samples after subtraction of background noise.
T72 1454-1699 Sentence denotes After proceeding to structural confirmation based on tandem mass spectrometry (MS/MS) spectra, the consolidated plasma metabolome finally contained 1,002 metabolites (598 lipids and 404 polar metabolites) quantitated using 71 internal standards.
T73 1700-1770 Sentence denotes Table 1 Demographics and Baseline Characteristics of COVID-19 Patients
T74 1771-1841 Sentence denotes Total (n = 50) Mild (n = 18) Moderate (n = 19) Severe (n = 13) p Value
T75 1842-1857 Sentence denotes Characteristics
T76 1858-1942 Sentence denotes Age, years 43.0 (34.3–53.8) 32.0 (22.3–40.0) 45.0 (38.0–53.5) 50.0 (40.0–78.0) 0.001
T77 1943-2050 Sentence denotes Onset of symptom to hospital admission, days 5.0 (3.0–8.0) 4.0 (2.0–5.0) 6.0 (4.0–7.0) 8.0 (5.0–10.0) 0.023
T78 2051-2155 Sentence denotes Duration of hospitalization, days 19.0 (11.0–27.0) 8.5 (5.3–19.0) 19.0 (13.0–27.0) 27.0 (20.0–36.0) 0.02
T79 2156-2165 Sentence denotes Sex 0.525
T80 2166-2204 Sentence denotes  Men 30 (60%) 9 (50%) 12 (63%) 9 (69%)
T81 2205-2244 Sentence denotes  Women 20 (40%) 9 (50%) 7 (37%) 4 (31%)
T82 2245-2302 Sentence denotes Exposure to Wuhan 26 (52%) 13 (72%) 7 (37%) 6 (46%) 0.087
T83 2303-2357 Sentence denotes Any comorbidity 18 (36%) 3 (17%) 7 (37%) 8 (62%) 0.037
T84 2358-2403 Sentence denotes  Hypertension 8 (16%) 0 3 (16%) 5 (38%) 0.016
T85 2404-2450 Sentence denotes  Diabetes 5 (10%) 1 (6%) 2 (11%) 2 (15%) 0.664
T86 2451-2486 Sentence denotes  Malignancy 1 (2%) 0 0 1 (8%) 0.234
T87 2487-2515 Sentence denotes  HIV 1 (2%) 0 0 1 (8%) 0.234
T88 2516-2563 Sentence denotes  Chronic liver disease 2 (4%) 0 0 2 (15%) 0.052
T89 2564-2594 Sentence denotes Death 2 (4%) 0 0 2 (15%) 0.052
T90 2595-2613 Sentence denotes Signs and Symptoms
T91 2614-2661 Sentence denotes Fever 42 (84%) 13 (72%) 18 (95%) 11 (85%) 0.175
T92 2662-2690 Sentence denotes Highest temperature,°C 0.702
T93 2691-2728 Sentence denotes  <37.3 8 (16%) 5 (28%) 1 (5%) 2 (15%)
T94 2729-2772 Sentence denotes  37.3–38.0 12 (24%) 4 (22%) 5 (26%) 3 (23%)
T95 2773-2817 Sentence denotes  38.1–39.0 22 (44%) 6 (33%) 10 (53%) 6 (46%)
T96 2818-2856 Sentence denotes  >39.0 8 (16%) 3 (17%) 3 (16%) 2 (15%)
T97 2857-2903 Sentence denotes Cough 31 (62%) 8 (44%) 12 (63%) 11 (85%) 0.075
T98 2904-2956 Sentence denotes Expectoration 15 (30%) 3 (17%) 5 (26%) 7 (54%) 0.076
T99 2957-2992 Sentence denotes Rhinorrhoea 1 (2%) 1 (6%) 0 0 0.404
T100 2993-3051 Sentence denotes Myalgia or fatigue 23 (46%) 5 (28%) 7 (37%) 11 (85%) 0.004
T101 3052-3079 Sentence denotes Nausea and vomiting 0 0 0 0
T102 3080-3129 Sentence denotes Sore throat 7 (14%) 3 (17%) 2 (11%) 2 (15%) 0.853
T103 3130-3180 Sentence denotes Shortness of breath 6 (12%) 0 1 (5%) 5 (38%) 0.003
T104 3181-3215 Sentence denotes Chest pain 1 (2%) 0 0 1 (8%) 0.234
T105 3216-3255 Sentence denotes Diarrhea 5 (10%) 3 (17%) 2 (11%) 0 0.31
T106 3256-3725 Sentence denotes Data were median (interquartile range, IQR), or n (%). p values comparing mild, moderate, and severe were computed using the χ2 test (sex, exposure to Wuhan, comorbidities, death, fever, highest temperature, cough, expectoration, rhinorrhea, myalgia or fatigue, nausea and vomiting, sore throat, shortness of breath, chest pain, and diarrhea), one-way ANOVA (onset of symptom to hospital admission, duration of hospitalization, and BMI), or Kruskal-Wallis H test (age).
T107 3726-3761 Sentence denotes COVID-19, coronavirus disease 2019.
T108 3762-3781 Sentence denotes See also Figure S1.