LitCovid-sentences  

PMC:7306567 / 9911-13083 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T64 0-43 Sentence denotes Clinical presentation and diagnosis of IAPA
T65 44-194 Sentence denotes A retrospective Belgian study of influenza patients admitted to ICU between September 2009 and March 2011 showed that 9 of 40 (23%) patients had IAPA.
T66 195-316 Sentence denotes Four cases (44%) were proven despite not being immunocompromised according to the EORTC/MSGERC consensus definitions [7].
T67 317-398 Sentence denotes The median time between influenza diagnosis and IAPA was 2 days (range 0–4 days).
T68 399-499 Sentence denotes All IAPA patients had positive BAL GM, and 78% had positive serum GM, despite not being neutropenic.
T69 500-741 Sentence denotes Eighty-nine percent of patients had Aspergillus growth in BAL culture (almost exclusively Aspergillus fumigatus), and 55% of patients had endobronchial lesions observed during bronchoscopy, possibly indicating invasive tracheobronchitis [7].
T70 742-849 Sentence denotes Similar performance characteristics of BAL GM and culture were reported in two other cohort studies [8, 9].
T71 850-990 Sentence denotes BAL sampling is thus an important diagnostic procedure as serum GM can be negative and sputum/tracheal aspirate cultures can remain sterile.
T72 991-1147 Sentence denotes Lesions that are suggestive of invasive mold disease on imaging in neutropenic patients, such as the halo sign, are often absent in critically ill patients.
T73 1148-1281 Sentence denotes However, in some IAPA patients with autopsy-confirmed Aspergillus tracheobronchitis, chest CT demonstrated peribronchial infiltrates.
T74 1282-1491 Sentence denotes The main diagnostic clue for airway-invasive Aspergillus tracheobronchitis is epithelial plaques, pseudomembranes or ulcers that can be visualized via bronchoscopy, as radiological features may be subtle [31].
T75 1492-1725 Sentence denotes Worsening of radiographic pulmonary infiltrates in patients with influenza is often attributed to progression of ARDS or bacterial infection, leading to a change of antimicrobial therapy without performing diagnostic procedures [32].
T76 1726-2000 Sentence denotes Patients who survived IAPA received antifungal therapy much earlier than those who did not (2 days after diagnosis of influenza among survivors versus 9 days among non-survivors) [8], suggesting that early diagnosis and administration of antifungal therapy may be important.
T77 2001-2209 Sentence denotes Lateral flow tests have recently become available as an alternative for diagnosing IPA (AspLFD, OLM Diagnostics and the sōna Aspergillus GM, IMMY) showing overall good performance in hematology patients [33].
T78 2210-2372 Sentence denotes The very quick assessment, with results available within 30–45 min, makes this type of test very attractive for the management of IAPA and use in clinical trials.
T79 2373-2451 Sentence denotes However, lateral flow tests have not yet been validated in the ICU population.
T80 2452-2643 Sentence denotes IAPA needs to be considered in patients admitted to the ICU with influenza and where indicated these patients should undergo early BAL for Aspergillus antigen testing, culture and microscopy.
T81 2644-2873 Sentence denotes Patients who test positive require anti-Aspergillus therapy, and the BAL fluid sample should be fast-tracked for azole resistance testing by PCR (and culture when positive) in regions with high (> 5%) azole resistance rates [34].
T82 2874-2992 Sentence denotes This would enable diagnostic assessment and initiation of adequate antifungal therapy within 24–48 h of ICU admission.
T83 2993-3172 Sentence denotes Diagnostic workup for IAPA may be repeated in patients deteriorating while on antivirals and/or appropriate antibiotics or when initiating corticosteroid treatment is unavoidable.