LitCovid-sentences  

PMC:7306567 / 17643-19217 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T117 0-77 Sentence denotes Discussion on antifungal treatment options and challenges for IAPA in the ICU
T118 78-414 Sentence denotes A specific drug–drug interaction is relevant for patients with IAPA given the fact that co-infections with S. aureus are frequently observed; undetectable voriconazole levels have been observed in 11 of 20 patients, who were concomitantly treated with flucloxacillin [53], but the mechanisms of interaction are not yet fully understood.
T119 415-473 Sentence denotes Similar interactions have not been seen with other azoles.
T120 474-575 Sentence denotes Many other drug interactions with azoles and drugs commonly deployed in the ICU can be expected [45].
T121 576-782 Sentence denotes Aerosolized antifungal treatment may be a useful adjunctive therapy to systemic antifungal therapy for patients with confirmed Aspergillus tracheobronchitis, to achieve good endobronchial exposure [35, 54].
T122 783-965 Sentence denotes However, dense lipophilic plaques in the trachea may be difficult to penetrate and more research is needed into when and how to use aerosolized antifungals as well as their efficacy.
T123 966-1199 Sentence denotes The ECCMID/ECMM/ERS Aspergillus guideline reviewed the teratogenic and mutagenic potential of antifungals in early pregnancy and recommends that azoles should be avoided, with polyenes being considered the preferred therapy [43, 55].
T124 1200-1309 Sentence denotes Thus, for pregnant patients at risk of IAPA a diagnostic approach was preferred above antifungal prophylaxis.
T125 1310-1390 Sentence denotes There is little evidence on the impact of ECMO on antifungal drug exposure [56].
T126 1391-1448 Sentence denotes For the echinocandins, an impact of ECMO is not expected.
T127 1449-1574 Sentence denotes Experts felt that, given these uncertainties, TDM of any antifungal used would be advised to ensure sufficient drug exposure.