| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T101 |
0-45 |
Sentence |
denotes |
Rationale for antifungal prophylaxis for IAPA |
| T102 |
46-242 |
Sentence |
denotes |
In settings with high IAPA rates in ICU patients with influenza pneumonia, an antifungal prophylaxis strategy might be appropriate, particularly as IAPA typically occurs early after ICU admission. |
| T103 |
243-350 |
Sentence |
denotes |
However, there is currently no mold-active antifungal agent licensed for prophylaxis of IA in ICU patients. |
| T104 |
351-505 |
Sentence |
denotes |
Posaconazole (POS) prophylaxis reduces the prevalence of IA in neutropenic AML patients and those with graft-versus-host disease following alloHCT [2, 3]. |
| T105 |
506-629 |
Sentence |
denotes |
Based on this proof-of-principle, it has been hypothesized that POS prophylaxis can reduce IAPA prevalence in ICU patients. |
| T106 |
630-805 |
Sentence |
denotes |
Intravenous (IV) administration of POS prophylaxis in the ICU is favored in patients on mechanical ventilation or with a high likelihood of malabsorption of oral formulations. |
| T107 |
806-908 |
Sentence |
denotes |
POS IV formulation should be administered through a central catheter due to its acidity (pH 3.2) [42]. |
