PMC:7306567 / 135-1918 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3 0-7 Sentence denotes Purpose
T4 8-135 Sentence denotes Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU).
T5 136-391 Sentence denotes Classification of patients with influenza-associated pulmonary aspergillosis (IAPA) using the current definitions for invasive fungal diseases has proven difficult, and our aim was to develop case definitions for IAPA that can facilitate clinical studies.
T6 393-400 Sentence denotes Methods
T7 401-598 Sentence denotes A group of 29 international experts reviewed current insights into the epidemiology, diagnosis and management of IAPA and proposed a case definition of IAPA through a process of informal consensus.
T8 600-607 Sentence denotes Results
T9 608-710 Sentence denotes Since IAPA may develop in a wide range of hosts, an entry criterion was proposed and not host factors.
T10 711-872 Sentence denotes The entry criterion was defined as a patient requiring ICU admission for respiratory distress with a positive influenza test temporally related to ICU admission.
T11 873-997 Sentence denotes In addition, proven IAPA required histological evidence of invasive septate hyphae and mycological evidence for Aspergillus.
T12 998-1305 Sentence denotes Probable IAPA required the detection of galactomannan or positive Aspergillus culture in bronchoalveolar lavage (BAL) or serum with pulmonary infiltrates or a positive culture in upper respiratory samples with bronchoscopic evidence for tracheobronchitis or cavitating pulmonary infiltrates of recent onset.
T13 1306-1555 Sentence denotes The IAPA case definitions may be useful to classify patients with COVID-19-associated pulmonary aspergillosis (CAPA), while awaiting further studies that provide more insight into the interaction between Aspergillus and the SARS-CoV-2-infected lung.
T14 1557-1567 Sentence denotes Conclusion
T15 1568-1783 Sentence denotes A consensus case definition of IAPA is proposed, which will facilitate research into the epidemiology, diagnosis and management of this emerging acute and severe Aspergillus disease, and may be of use to study CAPA.