| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T97 |
0-223 |
Sentence |
denotes |
Live-attenuated vaccines are intrinsically immunogenic (e.g., due to the presence of viral DNA), but extensive safety tests are required due to the rare possibility of reversion to a pathogenic form able to cause infection. |
| T98 |
224-463 |
Sentence |
denotes |
Vaccine candidates based in this application have previously been designed for SARS-CoV with high stability.72,73 Recombinant-protein vaccines and inactivated vaccines are safer but might require adjuvants to increase their immunogenicity. |
| T99 |
464-534 |
Sentence |
denotes |
In the context of SARS-CoV-2, adjuvants are important for two reasons. |
| T100 |
535-809 |
Sentence |
denotes |
First, adjuvants might increase the efficacy of the vaccine, especially in subjects with impaired immunological function, such as the elderly, or in subjects with comorbidities resulting in immune dysfunctions; in these patient cohorts, SARS-CoV-2 has a high lethality rate. |
| T101 |
810-968 |
Sentence |
denotes |
Second, adjuvants can reduce the amount of vaccine protein(s) required per dose, which could facilitate scaling-up vaccine production in a reduced time frame. |
