| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T67 |
0-387 |
Sentence |
denotes |
In the context of nanomedicine, many nanomaterials have been developed, ranging from polymers48 to dendrimers,49 oligomers, NPs,50 liposomes,51 and small molecules.52 However, successful clinical translation has been hindered by the fact that, upon dilution, these compounds lose efficacy as the virus-compound complex dissociates leaving viruses free to restart their replication cycle. |
| T68 |
388-1126 |
Sentence |
denotes |
Recently, it has been shown that this limitation can be overcome by synthesizing NPs that, after binding, are able to inhibit viral infectivity irreversibly by permanently damaging the virion, refueling the hope for a true, broad-spectrum antiviral drug.53 Because the focus is also on the development of a drug specific to SARS-CoV-2, a good entry inhibitor could be based on blocking the S spike protein interaction with the cellular ACE2 receptor.19,21−23 Regardless of the specific approach, it is imperative that novel, effective antivirals be based on compounds that exhibit very low or negligible toxicity profiles, as patients will most likely need to receive those drugs for extended periods of time and will already be weakened. |
| T69 |
1127-1223 |
Sentence |
denotes |
For these reasons, when designing antiviral drugs, clearance mechanisms have to be kept in mind. |
| T70 |
1224-1746 |
Sentence |
denotes |
An example of this process is the recent redesign of broad-spectrum antiviral NPs into equally effective modified cyclodextrins.54 Moreover, nanotechnology may offer nanotheranostic approaches to fill the existing gap between diagnostics and therapy.55−57 The simultaneous management of both diagnostics and therapy for those suffering from COVID-19 or in future pandemics, as for many other diseases, is an additional potential strategy to take into consideration in which nanomaterials have proven to be effective tools. |
| T71 |
1747-2057 |
Sentence |
denotes |
The advantages of the capabilities of nanotechnology and nanomaterials for combined therapeutics and diagnostics has been widely explored in cancer research; however, there have been considerable efforts in the past few years to extend the scope of this approach to other areas including infectious diseases.58 |
