Id |
Subject |
Object |
Predicate |
Lexical cue |
T56 |
0-258 |
Sentence |
denotes |
In addition to discussing immune-based approaches, because the lung is the most critically affected organ, we will center our discussion on the various options to inactivate the virus in the deep lung and to target the essential host cells for drug delivery. |
T57 |
259-421 |
Sentence |
denotes |
The virus reaches the alveoli and enters alveolar epithelial type II cells (AECII), due to the relatively high abundance of ACE2 and a permissive cellular milieu. |
T58 |
422-573 |
Sentence |
denotes |
These cells serve as a reservoir of the virus, which finally spreads throughout the lung, leading to the lung function impairment seen in severe cases. |
T59 |
574-796 |
Sentence |
denotes |
Airborne nanomaterials are optimally suited to penetrate into the deep lung due to the physicochemical properties of such aerosols, existing on the same size scale particles that penetrate most readily to the deep airways. |
T60 |
797-956 |
Sentence |
denotes |
Hence, nanomedicine is already actively pursuing ideas to deliver drugs, therapeutic proteins, and mRNAs by exploiting nanodevices for pulmonary delivery.38,39 |