PMC:7294857 / 2165-5294 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T19 0-27 Sentence denotes Introduction and background
T20 28-190 Sentence denotes As of April 16 2020, there are a total of 1,991,562 confirmed cases and 130,885 reported deaths due to this deadly virus, which is given the name of COVID-19 [1].
T21 191-234 Sentence denotes The fatality rate of the virus is 2.3% [2].
T22 235-390 Sentence denotes The death rate is higher in people of age above 80 and those having comorbid conditions like hypertension, diabetes, and chronic respiratory disorders [2].
T23 391-558 Sentence denotes Approximately 48% of the people who have had fatal outcomes had a comorbid condition, 30% were hypertensive, 19% were diabetics, and 8% had coronary heart disease [3].
T24 559-624 Sentence denotes This virus belongs to the family of viruses called Coronaviridae.
T25 625-821 Sentence denotes There are four genera of coronaviruses (ɑ,𝛃,ɣ,𝝳), COVID-19 belongs to the beta-coronaviruses as its genome matches 88% and 50% to the other coronaviruses which are SARS and MERS, respectively [4].
T26 822-970 Sentence denotes It is believed that initially, the virus transmitted from animals to humans, and among humans, the virus transmitted via respiratory droplets [3,5].
T27 971-1065 Sentence denotes The virus has very high transmissibility as it has affected the whole world in a brief period.
T28 1066-1297 Sentence denotes When infected, there is an incubation period of 2-14 days after which the patient develops the symptoms of high fever, cough, shortness of breath, myalgias, and fatigue, and the virus is contagious during the incubation period [6].
T29 1298-1425 Sentence denotes The COVID-19 in susceptible patients causes pneumonia, which rapidly progresses to acute respiratory distress syndrome (ARDS). 
T30 1426-1659 Sentence denotes The exact pathogenesis is currently unknown; however, it is suggested that it is most likely to be similar to that of SARS CoV and MERS CoV, which attach to ACE 2 enzyme on the cell surface with the help of their glycoprotein spikes.
T31 1660-1798 Sentence denotes After the entry of the virus, its antigens are presented to major histocompatibility complex (MHC) via the antigen-presenting cells (APC).
T32 1799-1904 Sentence denotes Then these antigens are recognized by specific cytotoxic lymphocytes that destroy the infected cells [4].
T33 1905-2082 Sentence denotes On chest X-ray and chest computed tomography (CT), ground-glass opacities, patchy consolidation, and interstitial changes at the periphery of the lungs are typical findings [7].
T34 2083-2186 Sentence denotes Real-time polymerase chain reaction (RT-PCR) is used to make the diagnosis of the suspected cases [4]. 
T35 2187-2365 Sentence denotes There is currently no recommended treatment for COVID-19, only supportive care like oxygen, and mechanical ventilation is provided to patients in severe respiratory distress [2].
T36 2366-2560 Sentence denotes Two drugs, remdesevir and chloroquine, have shown some good results, but it is too soon to state their efficacy as there is limited data on the effectiveness of these drugs in COVID-19 patients.
T37 2561-2707 Sentence denotes Researchers are also considering the passive immunization of critical patients with the convalescent sera, and it has shown some good results [8].
T38 2708-2830 Sentence denotes As we know, currently, there is limited knowledge available on the pathophysiology and treatment options for the COVID-19.
T39 2831-3129 Sentence denotes And what little information is known is not well organized yet. In this review article, we aim to identify and highlight clinical features, pathological and radiological findings, and possible treatment options for COVID-19 patients and to organize the little information we have on this pathogen.