PMC:7293470 / 5518-6113 11 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T26 | 85-235 | Sentence | denotes | DRhQ is a bifunctional drug comprised of the HLA-DRα1 domain covalently linked to human myelin oligodendroglial cell glycoprotein (MOG)-35-55 peptide. |
| T27 | 236-495 | Sentence | denotes | Due to its unique design, DRhQ can bind to and inhibit both T cell receptors and the MHC “invariant” chain, CD74, that serves as the receptor for the proinflammatory homologs, MIF and MIF2, resulting in blockade of multiple contributors to the Cytokine Storm. |
| T28 | 496-507 | Sentence | denotes | DRhQ image: |
| T29 | 508-595 | Sentence | denotes | Green = DRα1L50Q domain; Dark green line = linker; Black = MOG-35-55 peptide extension. |