| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T7 |
22-166 |
Sentence |
denotes |
We designed bisubstrate inhibitors by mimicking the transition state of the 2′-O-methylation of the cap RNA in order to block viral 2′-O MTases. |
| T8 |
167-301 |
Sentence |
denotes |
This work resulted in the synthesis of 16 adenine dinucleosides with both adenosines connected by various nitrogen-containing linkers. |
| T9 |
302-569 |
Sentence |
denotes |
Unexpectedly, all the bisubstrate compounds were barely active against 2′-O MTases of several flaviviruses or SARS-CoV but surprisingly, seven of them showed efficient and specific inhibition against SARS-CoV N7-MTase (nsp14) in the micromolar to submicromolar range. |
