| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T137 |
65-152 |
Sentence |
denotes |
Compounds were previously dissolved in 100% DMSO. n.i: no inhibition detected at 50 μM. |
| T138 |
153-280 |
Sentence |
denotes |
Unexpectedly, all the bisubstrate compounds were barely active against the 2′-O MTases of flaviviruses or coronavirus SARS-CoV. |
| T139 |
281-350 |
Sentence |
denotes |
In contrast, most of the compounds displayed inhibition of N7-MTases. |
| T140 |
351-530 |
Sentence |
denotes |
Dinucleoside 2 bearing the amino acid chain of the SAM showed some significant inhibition of both viral N7-MTases with a better activity on Vaccinia D1-D12 than on SARS-CoV nsp14. |
| T141 |
531-698 |
Sentence |
denotes |
However, compound 2 also displayed a potent inhibition of hRNMT in the same range as the viral MTases displaying a lack of specificity against human and viral enzymes. |
