PMC:7289100 / 47892-49286 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T315 0-72 Sentence denotes 14 Probable histopathological signs of autoimmune reactions in COVID-19
T316 73-218 Sentence denotes Based upon the possibility to detect autoimmune reactions by morphological methods we analyzed autopsies from 18 deceased patients from COVID-19.
T317 219-341 Sentence denotes The pathological investigation was done by using bright lineage of immunohistochemistry (CD2, 3, 5, 7, 8, 20, 31, 34, 69).
T318 342-426 Sentence denotes Our study allowed us to demonstrate the role of different mechanisms of death [128].
T319 427-653 Sentence denotes Of special interest was the diffuse infiltration of the lungs, along with focal infiltration of the kidney, liver, intestine, adrenals, pancreas and pericard by lymphocytes, which were seen in different grade in all our cases.
T320 654-966 Sentence denotes In order to understand its nature we were able to prove that the infiltrate was dominated by T lymphocytes (CD3+), and the most numerous of them were CD8+ suppressors, observed in the lungs (Fig. 1a), adrenals (Fig. 1b), liver (Fig. 1c), intestine (Fig. 1d) and other organs partly accompanied by tissue lesions.
T321 967-1157 Sentence denotes Taking in to consideration that one of the most important mechanisms of autoimmune reactions is CD8+ T Cell mediated cytotoxicity, we assumed that the findings confirm an autoimmune process.
T322 1158-1252 Sentence denotes Further complex studies will hopefully allow us to optimize the strategy of treatment as well.
T323 1253-1320 Sentence denotes Fig. 1 Infiltration by CD8+ suppressor T-cells of different organs.
T324 1321-1325 Sentence denotes IHC.
T325 1326-1344 Sentence denotes Magnification 100.
T326 1345-1394 Sentence denotes A-Lungs, B -Adrenal gland, C-liver, D- intestine.