LitCovid-sentences  

PMC:7289100 / 44088-47264 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T273 0-182 Sentence denotes Notwithstanding the current wave of intensive worldwide research, the ethiopathology of the diseases induced by the SARS-CoV-2 infection is the central question that remains obscure.
T274 183-372 Sentence denotes One likely explanation is that the heterogeneity and multitude of the disorders induced by the current pandemic derive from molecular mimicry phenomena between the virus and human proteins.
T275 373-620 Sentence denotes The scientific rationale is that, following the infection, the immune responses raised against SARS-CoV-2 may cross-react with human proteins that share peptide sequences with the virus, in this way leading to autoimmune pathologic sequelae [120].
T276 621-840 Sentence denotes Actually, a recent report [121] militates in this direction and likely explains lungs and airways dysfunctions through the sharing of peptides between SARS-CoV-2 glycoprotein and alveolar lung surfactant proteins [121].
T277 841-1188 Sentence denotes Moreover, in the clinical context exposed above, it is of note to report that Sars.CoV-2 shares 6 minimal immune determinants (KTVLK, TPEEH, RETMS, PFVVS, GLEAP, ICLLQ) with the Kawasaki antigen Inositol-trisphosphate 3-kinase C [122], thus highlighting as likely cross-reactions and consequent autoimmune Kawasaki disease in predisposed subjects.
T278 1189-1324 Sentence denotes Even more impressing it appears the heptapeptide sharing between the human proteome and the viral spike glycoprotein shown in Table 1 .
T279 1325-1373 Sentence denotes The clinical scenario that emerges is upsetting.
T280 1374-1534 Sentence denotes Indeed, the list of proteins reported in the table – when altered – configurate almost all the diseases that have been described in association with SARS-CoV-2.
T281 1535-1861 Sentence denotes Two examples from the table are 1) Histone-lysine N-methyltransferase 2C that may associate with neurodevelopmental disorders., seizures, behavioral abnormalities [123], and 2) Interleukin-7 that plays a central, critical role in the regulation of the immune system and associates with severe lymphopenia when deficient [124].
T282 1862-1952 Sentence denotes Table 1 Heptapeptide sharing between SARS-CoV-2 spike glycoprotein and the human proteins.
T283 1953-1979 Sentence denotes Peptide Human Protein Name
T284 1980-2013 Sentence denotes SSTASAL 40S ribosomal protein S13
T285 2014-2035 Sentence denotes KLNDLCF Interleukin-7
T286 2036-2076 Sentence denotes FLPFFSN OTU domain-containing protein 6A
T287 2077-2096 Sentence denotes EIDRLNE Protein SET
T288 2097-2142 Sentence denotes IGAGICA Hepatitis A virus cellular receptor 2
T289 2143-2165 Sentence denotes EIDRLNE Protein SETSIP
T290 2166-2203 Sentence denotes LDKYFKN Follistatin-related protein 1
T291 2204-2255 Sentence denotes VSGTNGT Lysosome-associated membrane glycoprotein 1
T292 2256-2307 Sentence denotes FKNLREF Isovaleryl-CoA dehydrogenase, mitochondrial
T293 2308-2375 Sentence denotes LPPLLTD Maestro heat-like repeat-containing protein family member 9
T294 2376-2407 Sentence denotes DKVFRSS Zinc finger protein 528
T295 2408-2444 Sentence denotes LVKQLSS E3 SUMO-protein ligase PIAS1
T296 2445-2494 Sentence denotes VTLADAG Non-receptor tyrosine-protein kinase TNK1
T297 2495-2552 Sentence denotes RRARSVAS Amiloride-sensitive sodium channel subunit alpha
T298 2553-2596 Sentence denotes SPRRARS Hermansky-Pudlak syndrome 1 protein
T299 2597-2613 Sentence denotes KVEAEVQ EMILIN-3
T300 2614-2672 Sentence denotes TRFQTLL Disheveled-associated activator of morphogenesis 2
T301 2673-2726 Sentence denotes VYSTGSN Neural cell adhesion molecule L1-like protein
T302 2727-2770 Sentence denotes GLTVLPP FH1/FH2 domain-containing protein 3
T303 2771-2822 Sentence denotes SLLIVNN ATP-binding cassette sub-family A member 10
T304 2823-2857 Sentence denotes DEDDSEPV Unconventional myosin-XVI
T305 2858-2900 Sentence denotes NASVVNI Thyroid adenoma-associated protein
T306 2901-2937 Sentence denotes LIRAAEI Unconventional myosin-XVIIIa
T307 2938-2964 Sentence denotes TGRLQSL Neuron navigator 3
T308 2965-3010 Sentence denotes DEVRQIA Histone-lysine N-methyltransferase 2C
T309 3011-3049 Sentence denotes SSSGWTA Transmembrane protein KIAA1109
T310 3050-3123 Sentence denotes Data on protein function/disease from Uniprot (https://www.uniprot.org/).
T311 3124-3176 Sentence denotes Sequential overlapping heptapeptides are given bold.