LitCovid-sentences  

PMC:7289100 / 44027-47264 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T271 0-30 Sentence denotes 12 Covid-19 and autoimmunity:
T272 31-60 Sentence denotes The role of molecular mimicry
T273 61-243 Sentence denotes Notwithstanding the current wave of intensive worldwide research, the ethiopathology of the diseases induced by the SARS-CoV-2 infection is the central question that remains obscure.
T274 244-433 Sentence denotes One likely explanation is that the heterogeneity and multitude of the disorders induced by the current pandemic derive from molecular mimicry phenomena between the virus and human proteins.
T275 434-681 Sentence denotes The scientific rationale is that, following the infection, the immune responses raised against SARS-CoV-2 may cross-react with human proteins that share peptide sequences with the virus, in this way leading to autoimmune pathologic sequelae [120].
T276 682-901 Sentence denotes Actually, a recent report [121] militates in this direction and likely explains lungs and airways dysfunctions through the sharing of peptides between SARS-CoV-2 glycoprotein and alveolar lung surfactant proteins [121].
T277 902-1249 Sentence denotes Moreover, in the clinical context exposed above, it is of note to report that Sars.CoV-2 shares 6 minimal immune determinants (KTVLK, TPEEH, RETMS, PFVVS, GLEAP, ICLLQ) with the Kawasaki antigen Inositol-trisphosphate 3-kinase C [122], thus highlighting as likely cross-reactions and consequent autoimmune Kawasaki disease in predisposed subjects.
T278 1250-1385 Sentence denotes Even more impressing it appears the heptapeptide sharing between the human proteome and the viral spike glycoprotein shown in Table 1 .
T279 1386-1434 Sentence denotes The clinical scenario that emerges is upsetting.
T280 1435-1595 Sentence denotes Indeed, the list of proteins reported in the table – when altered – configurate almost all the diseases that have been described in association with SARS-CoV-2.
T281 1596-1922 Sentence denotes Two examples from the table are 1) Histone-lysine N-methyltransferase 2C that may associate with neurodevelopmental disorders., seizures, behavioral abnormalities [123], and 2) Interleukin-7 that plays a central, critical role in the regulation of the immune system and associates with severe lymphopenia when deficient [124].
T282 1923-2013 Sentence denotes Table 1 Heptapeptide sharing between SARS-CoV-2 spike glycoprotein and the human proteins.
T283 2014-2040 Sentence denotes Peptide Human Protein Name
T284 2041-2074 Sentence denotes SSTASAL 40S ribosomal protein S13
T285 2075-2096 Sentence denotes KLNDLCF Interleukin-7
T286 2097-2137 Sentence denotes FLPFFSN OTU domain-containing protein 6A
T287 2138-2157 Sentence denotes EIDRLNE Protein SET
T288 2158-2203 Sentence denotes IGAGICA Hepatitis A virus cellular receptor 2
T289 2204-2226 Sentence denotes EIDRLNE Protein SETSIP
T290 2227-2264 Sentence denotes LDKYFKN Follistatin-related protein 1
T291 2265-2316 Sentence denotes VSGTNGT Lysosome-associated membrane glycoprotein 1
T292 2317-2368 Sentence denotes FKNLREF Isovaleryl-CoA dehydrogenase, mitochondrial
T293 2369-2436 Sentence denotes LPPLLTD Maestro heat-like repeat-containing protein family member 9
T294 2437-2468 Sentence denotes DKVFRSS Zinc finger protein 528
T295 2469-2505 Sentence denotes LVKQLSS E3 SUMO-protein ligase PIAS1
T296 2506-2555 Sentence denotes VTLADAG Non-receptor tyrosine-protein kinase TNK1
T297 2556-2613 Sentence denotes RRARSVAS Amiloride-sensitive sodium channel subunit alpha
T298 2614-2657 Sentence denotes SPRRARS Hermansky-Pudlak syndrome 1 protein
T299 2658-2674 Sentence denotes KVEAEVQ EMILIN-3
T300 2675-2733 Sentence denotes TRFQTLL Disheveled-associated activator of morphogenesis 2
T301 2734-2787 Sentence denotes VYSTGSN Neural cell adhesion molecule L1-like protein
T302 2788-2831 Sentence denotes GLTVLPP FH1/FH2 domain-containing protein 3
T303 2832-2883 Sentence denotes SLLIVNN ATP-binding cassette sub-family A member 10
T304 2884-2918 Sentence denotes DEDDSEPV Unconventional myosin-XVI
T305 2919-2961 Sentence denotes NASVVNI Thyroid adenoma-associated protein
T306 2962-2998 Sentence denotes LIRAAEI Unconventional myosin-XVIIIa
T307 2999-3025 Sentence denotes TGRLQSL Neuron navigator 3
T308 3026-3071 Sentence denotes DEVRQIA Histone-lysine N-methyltransferase 2C
T309 3072-3110 Sentence denotes SSSGWTA Transmembrane protein KIAA1109
T310 3111-3184 Sentence denotes Data on protein function/disease from Uniprot (https://www.uniprot.org/).
T311 3185-3237 Sentence denotes Sequential overlapping heptapeptides are given bold.