| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T262 |
0-46 |
Sentence |
denotes |
11 Interleukin-1 (IL-1) inhibitors – Anakinra |
| T263 |
47-104 |
Sentence |
denotes |
Anakinra is a recombinant human IL-1 receptor antagonist. |
| T264 |
105-445 |
Sentence |
denotes |
It is approved to treat rheumatoid arthritis and cryopyrin-associated periodic syndromes, and it is also used off-label for a variety of inflammatory conditions and severe chimeric antigen receptor T cell (CAR-T)-mediated cytokine release syndrome (CRS) and macrophage activation syndrome (MAS)/secondary hemophagocytic lymphohistiocytosis. |
| T265 |
446-551 |
Sentence |
denotes |
A case series of anakinra use in moderate to severe COVID-19 pneumonia has recently been published [118]. |
| T266 |
552-776 |
Sentence |
denotes |
This small study of 9 patients with moderate to severe Covid-19 pneumonia, who did not reach respiratory failure and were given anakinra (Anti-IL-1), serves as a proof of concept since all 9 patients had dropped their fever, |
| T267 |
777-848 |
Sentence |
denotes |
CRP levels had dropped and normalized in 5 out of 8 patients at day 11. |
| T268 |
849-919 |
Sentence |
denotes |
CT scans did not deteriorate and all were alive at the last follow up. |
| T269 |
920-1120 |
Sentence |
denotes |
Similar results were reached in a retrospective study from Italy of 16 patients with Covid-19 and adult respiratory distress syndrome who were managed with non-invasive ventilation outside of the ICU. |
| T270 |
1121-1246 |
Sentence |
denotes |
Treatment with high-dose anakinra was found to be safe and associated with clinical improvement in 72% of the patients [119]. |
