LitCovid-sentences  

PMC:7289100 / 41230-42777 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T251 0-61 Sentence denotes 10 Anti-IL-6 receptor antibodies – Tocilizumab and Sarilumab
T252 62-198 Sentence denotes IL-6 is a pleiotropic, pro-inflammatory cytokine produced by a variety of cell types, including lymphocytes, monocytes, and fibroblasts.
T253 199-309 Sentence denotes Infection by the related SARS-CoV induces a dose-dependent production of IL-6 from bronchial epithelial cells.
T254 310-453 Sentence denotes Elevations in IL-6 levels may be an important mediator when severe systemic inflammatory responses occur in patients with SARS-CoV-2 infection.
T255 454-691 Sentence denotes COVID-19-associated systemic inflammation and hypoxic respiratory failure is associated with an acute cytokine release, as indicated by elevated blood levels of IL-6, C-reactive protein (CRP), D-dimer, and ferritin [[114], [115], [116]].
T256 692-802 Sentence denotes Few clinical studies aiming to evaluate the efficacy of anti-IL-6 receptor blocker have been published so far.
T257 803-996 Sentence denotes In a report from China by Xu et al. the authors were able to show that tocilizumab effectively improved clinical symptoms as well as reversed the deterioration of sever Covid-19 patients [117].
T258 997-1247 Sentence denotes Within 5 days after tocilizumab, 15 of the 20 patients had lowered their oxygen intake and 19 of the 20 showed a noticeable improvement in the CT of the lungs, as well as a significant reduction in CRP levels which was noted in 16 of the 19 patients.
T259 1248-1336 Sentence denotes All patients have been discharged on an average of 15 days after the tocilizumab dosing.
T260 1337-1423 Sentence denotes Even though this is a small and uncontrolled study, the results seem to be impressive.
T261 1424-1547 Sentence denotes Over 20 randomized controlled trials with tocilizumab, or sarilumab as well as JAK-inhibitors as baricitinib, are underway.