LitCovid-sentences  

PMC:7289100 / 38587-41229 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T237 0-169 Sentence denotes Chloroquine and Hydroxychloroquine, are anti malarial drugs, used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
T238 170-246 Sentence denotes Both chloroquine and hydroxychloroquine (HCQ) have immunomodulatory effects.
T239 247-409 Sentence denotes In general, HCQ has fewer and less severe toxicities (including fewer propensities to prolong the QTc interval) and fewer drug-drug interactions than chloroquine.
T240 410-657 Sentence denotes The proposed mechanisms of action and rationale for use for COVID-19 of both drugs have to do with the increase of the endosomal pH, inhibiting fusion of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the host cell membranes.
T241 658-830 Sentence denotes Furthermore, Chloroquine inhibits glycosylation of the cellular angiotensin-converting enzyme 2 receptor, which may interfere with binding of SARS-CoV to the cell receptor.
T242 831-1096 Sentence denotes In vitro, both chloroquine and HCQ may block the transport of SARS-CoV-2 from early endosomes to endolysosomes, which may be required for release of the viral genome, and several studies have demonstrated in vitro activity of chloroquine against SARS-CoV [104,105].
T243 1097-1212 Sentence denotes Though HCQ has been administered to patients with Covid-19 there are to date no robust evidence supporting its use.
T244 1213-1484 Sentence denotes In a retrospective computerized database of 1317 positive subjects for Covid-19 out of a sample size of 14,520, a comparison was conducted between those who tested positive versus those who were found negative, in terms of the rate of administration of HCQ or colchicine.
T245 1485-1741 Sentence denotes The authors did not find any significant difference in terms of the rates of usage of either drug, thus they concluded that their findings raise doubts regarding the protective role of both these medication in the battle against SARS-CoV-2 infection [106].
T246 1742-1820 Sentence denotes Similar results were drawn by a study from a large medical center in New York.
T247 1821-1941 Sentence denotes The authors examined the association between HCQ use and intubation or death among a group of 1446 consecutive patients.
T248 1942-2060 Sentence denotes HCQ administration was not associated with either a greatly lowered or an increased risk of intubation or death [107].
T249 2061-2311 Sentence denotes Many similar reports came to the same conclusions [[108], [109], [110]], to the extent that the FDA has issued a safety alert and the American College of Physicians has as well recommended against the use of chloroquine or HCQ for COVID-19 [111,112].
T250 2312-2641 Sentence denotes Furthermore, an attempt to evaluate HCQ serum or plasma levels from various rheumatic disease patients receiving this treatment, found that these plasma or serum levels were unlikely to achieve the concentration shown to inhibit SARS-CoV-2 in vitro (average target 0.48 mg/L as opposed to the antiviral target of 4/1 mg/L) [113].