LitCovid-sentences  

PMC:7289100 / 38203-41228 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T234 0-60 Sentence denotes 9 Therapy - using rheumatologic drugs in COVID-19 infection
T235 61-159 Sentence denotes Many countries and organizations have published guidelines for treatment of the COVID-19 pandemic.
T236 160-383 Sentence denotes Of note are the Treatment Guidelines of the National Institutes of Health and the American College of Rheumatology guidance for the management of adult patients with rheumatic disease during the COVID-19 pandemic [102,103].
T237 384-553 Sentence denotes Chloroquine and Hydroxychloroquine, are anti malarial drugs, used to treat autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
T238 554-630 Sentence denotes Both chloroquine and hydroxychloroquine (HCQ) have immunomodulatory effects.
T239 631-793 Sentence denotes In general, HCQ has fewer and less severe toxicities (including fewer propensities to prolong the QTc interval) and fewer drug-drug interactions than chloroquine.
T240 794-1041 Sentence denotes The proposed mechanisms of action and rationale for use for COVID-19 of both drugs have to do with the increase of the endosomal pH, inhibiting fusion of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the host cell membranes.
T241 1042-1214 Sentence denotes Furthermore, Chloroquine inhibits glycosylation of the cellular angiotensin-converting enzyme 2 receptor, which may interfere with binding of SARS-CoV to the cell receptor.
T242 1215-1480 Sentence denotes In vitro, both chloroquine and HCQ may block the transport of SARS-CoV-2 from early endosomes to endolysosomes, which may be required for release of the viral genome, and several studies have demonstrated in vitro activity of chloroquine against SARS-CoV [104,105].
T243 1481-1596 Sentence denotes Though HCQ has been administered to patients with Covid-19 there are to date no robust evidence supporting its use.
T244 1597-1868 Sentence denotes In a retrospective computerized database of 1317 positive subjects for Covid-19 out of a sample size of 14,520, a comparison was conducted between those who tested positive versus those who were found negative, in terms of the rate of administration of HCQ or colchicine.
T245 1869-2125 Sentence denotes The authors did not find any significant difference in terms of the rates of usage of either drug, thus they concluded that their findings raise doubts regarding the protective role of both these medication in the battle against SARS-CoV-2 infection [106].
T246 2126-2204 Sentence denotes Similar results were drawn by a study from a large medical center in New York.
T247 2205-2325 Sentence denotes The authors examined the association between HCQ use and intubation or death among a group of 1446 consecutive patients.
T248 2326-2444 Sentence denotes HCQ administration was not associated with either a greatly lowered or an increased risk of intubation or death [107].
T249 2445-2695 Sentence denotes Many similar reports came to the same conclusions [[108], [109], [110]], to the extent that the FDA has issued a safety alert and the American College of Physicians has as well recommended against the use of chloroquine or HCQ for COVID-19 [111,112].
T250 2696-3025 Sentence denotes Furthermore, an attempt to evaluate HCQ serum or plasma levels from various rheumatic disease patients receiving this treatment, found that these plasma or serum levels were unlikely to achieve the concentration shown to inhibit SARS-CoV-2 in vitro (average target 0.48 mg/L as opposed to the antiviral target of 4/1 mg/L) [113].