LitCovid-sentences  

PMC:7289100 / 16045-17645 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T103 0-180 Sentence denotes The above considerations widely justify why aPL, detected with different assays, can be found in patients affected by COVID-19, sometimes associated with thrombosis but not always.
T104 181-421 Sentence denotes To our knowledge, no increased rate of miscarriages or fetal loss have been reported during SARS-CoV-2 pandemic so far, although some severe pregnancy complication, like those linked to aPL, such as HELLP syndrome were occasionally seen (A.
T105 422-456 Sentence denotes Lojacono, personal communication).
T106 457-628 Sentence denotes Whether pregnant women with COVID-19 have an increased rate of positive aPL during pregnancy is not known yet nor it is defined their possible impact on pregnancy outcome.
T107 629-668 Sentence denotes COVID-19 is a novel infectious disease.
T108 669-754 Sentence denotes The true relationship between this infection and aPL need to be further investigated.
T109 755-962 Sentence denotes However, according to the “second hit hypothesis” [60], the thrombogenic potential of aPL is magnified in the presence of an infection or a severe inflammatory state, which is often associated with COVID-19.
T110 963-1189 Sentence denotes Therefore, the search for aPL may be considered in the management of COVID-19 patients with vascular manifestations, as the detection of positive aPL would allow of the indication for an early adequate anticoagulant treatment.
T111 1190-1380 Sentence denotes In the case of aPL positivity, a follow-up testing after at least 12 weeks is warranted, in order to verify the persistence of aPL, which would suggest the post-infectious occurrence of APS.
T112 1381-1600 Sentence denotes In fact, APS is currently considered as a systemic autoimmune disease which is not limited to thrombosis and pregnancy morbidity and deserves specific long-term management including anticoagulation and immunomodulation.