LitCovid-sentences  

PMC:7288617 / 737-5693 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T6 0-215 Sentence denotes The diffusion of the novel coronavirus SARS-CoV-2 has rapidly spread worldwide, with several cases requiring intensive care and hospitalization because of the severe respiratory symptoms requiring assisting devices.
T7 216-371 Sentence denotes Miller Fisher syndrome (MFS), a variant of Guillain-Barré syndrome (GBS), is characterized by the clinical triad of ophthalmoplegia, ataxia, and areflexia.
T8 372-505 Sentence denotes About 60% of the above mentioned autoimmune syndromes can be infection-related by humoral and cellular cross-reactivity (Pusch et al.
T9 506-637 Sentence denotes 2018), most frequently gastrointestinal (Campylobacter jejuni) or respiratory tract infections, including influenza (Sellers et al.
T10 638-644 Sentence denotes 2017).
T11 645-870 Sentence denotes A previously healthy 50-year-old female, who worked as a healthcare assistant in an assisted living community, was admitted to the hospital with a diagnosis of bilateral pneumonia as a consequence of the SARS-CoV-2 infection.
T12 871-991 Sentence denotes The first symptoms 6 days before the admission were fever and cough, and a significant alteration of taste was reported.
T13 992-1177 Sentence denotes In the COVID-19 protected area, she was treated with antiviral therapy (lopinavir + ritonavir) for 14 days, hydroxychloroquine for 10 days, antibiotic therapy, and oxygen support (35%).
T14 1178-1331 Sentence denotes Ten days after hospital admission, the pulmonary function improved, but the patient developed neurological signs such as diplopia and facial paresthesia.
T15 1332-1632 Sentence denotes The first neurological examination found walking impairment due to ataxia, ophthalmoplegia with diplopia in vertical and lateral gaze, left upper arm cerebellar dysmetria, generalized areflexia, mild lower facial defects, and mild hypoesthesia in the left mandibular and maxillary branch of the face.
T16 1633-1771 Sentence denotes To exclude a posterior circulation stroke, a magnetic resonance imaging (MRI) of the brain was performed, which revealed no abnormalities.
T17 1772-1927 Sentence denotes The results of routine blood chemistry tests, anti-HIV, anti-HBV, and anti-HCV, and a panel of serological tests of autoimmune disorders were unremarkable.
T18 1928-2023 Sentence denotes The cerebrospinal fluid (CSF) analysis revealed clear CSF, normal pressure, and no blood cells.
T19 2024-2069 Sentence denotes The CSF/serum glucose ratio was 80/110 mg/dL.
T20 2070-2158 Sentence denotes CSF protein concentration was 74.9 mg/dL, higher compared with normal values < 45 mg/dL.
T21 2159-2378 Sentence denotes CSF culture and polymerase chain reaction (PCR) for possible organisms, such as bacteria, Mycobacterium tuberculosis, fungi, Herpes viruses, Enteroviruses, Japanese B virus, and Dengue viruses, yielded negative results.
T22 2379-2515 Sentence denotes Neurophysiological evaluation, as electroneuromyography, was not possible because of the limitations due to the COVID-19 protected area.
T23 2516-2635 Sentence denotes A panel of AGAbs, including anti-GM1, anti-GM2, anti-GM3, anti-GD1a, anti-GD1b, anti-GT1b, and anti-GQ1b, was negative.
T24 2636-2771 Sentence denotes Based on the clinical presentation and CFS findings, an intravenous immunoglobulin (IVIG) therapy was initiated at 0.4 g/kg for 5 days.
T25 2772-2956 Sentence denotes The neurological symptoms resolved 7 days after the start of IVIG treatment, with complete recovery of diplopia and dysmetria, and the patient was able to walk without signs of ataxia.
T26 2957-3066 Sentence denotes After the acute phase, the patient remained in the COVID-19 protected area still needing respiratory support.
T27 3067-3147 Sentence denotes No side effects were reported for the use of intravenous immunoglobulin therapy.
T28 3148-3328 Sentence denotes Fourteen days after the start of IVIG treatment, the patient has been discharged at home with the resolution of respiratory symptoms and only minor hyporeflexia at the lower limbs.
T29 3330-3340 Sentence denotes Discussion
T30 3341-3550 Sentence denotes The clinical presentation of the reported case, and CSF analysis showing a picture of albumin-cytological dissociation, suggested the diagnosis of MFS as previously described in the literature (Wakerley et al.
T31 3551-3557 Sentence denotes 2014).
T32 3558-3754 Sentence denotes The novelty of this case is represented by the diagnosis of MFS in a COVID-19 patient and by the clinical suggestion of treating neurological complications with intravenous immunoglobulin therapy.
T33 3755-3839 Sentence denotes Such neurological complications are common in respiratory infections (Sellers et al.
T34 3840-3945 Sentence denotes 2017); therefore, a cross-reactivity also for the new SARS-CoV-2 was speculated and reported (Zhao et al.
T35 3946-3998 Sentence denotes 2020) as for SARS-CoV affected patients (Baig et al.
T36 3999-4005 Sentence denotes 2020).
T37 4006-4112 Sentence denotes We did not find any presence of anti-GQ1b, usually explaining the symptoms of the disease (Wakerley et al.
T38 4113-4119 Sentence denotes 2014).
T39 4120-4231 Sentence denotes However, negative results for anti-GQ1b tests have been previously reported (Wattanasit and Sathirapanya 2020).
T40 4232-4382 Sentence denotes The particular cranial polyradiculoneuritis with the involvement of the facial and trigeminal nerve is well-known in MFS and MFS variants (Polo et al.
T41 4383-4404 Sentence denotes 1992; Wakerley et al.
T42 4405-4564 Sentence denotes 2014), and in the reported case, it was found being associated to an altered sense of taste, which is an uncommon feature of MFS but well-reported in COVID-19.
T43 4565-4689 Sentence denotes IVIG was found to be effective and safe to treat the reported neurological symptoms, showing complete recovery after 7 days.
T44 4690-4955 Sentence denotes In conclusion, this case report describes the characteristics of a MFS/cranial polyneuritis in a patient with COVID-19, and the clinical responses to intravenous immunoglobulin therapy, suggesting possible diagnosis and treatment options in this peculiar condition.