LitCovid-sentences  

PMC:7283670 / 31313-54593 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T244 0-74 Sentence denotes Table 3 Studies for diagnosis, prognosis and therapy of COVID‐19 patients
T245 75-317 Sentence denotes Study/region Study type/medical team Patient/median age/sex Diagnostic test Sample Inclusion criteria/residency Test results Most common symptoms/chronic disease Incubation period (day) Case fatality rate Diagnosis/prognosis/therapy
T246 318-565 Sentence denotes Wu et al. (2020), China Retrospective study/Chinese Center for Disease Control and Prevention 72,314; subjects: confirmed cases 44,672 (62%), suspected cases 16,186 (22%), diagnosed cases 10,567 (15%), asymptomatic cases 889 (1%)/age N = 44,672:
T247 566-569 Sentence denotes 80:
T248 570-588 Sentence denotes 3% (1,408), 30–79:
T249 589-609 Sentence denotes 87% (38,680), 20–29:
T250 610-628 Sentence denotes 8% (3,619), 10–19:
T251 629-643 Sentence denotes 1% (549), <10:
T252 644-914 Sentence denotes 1% (416) PCR Throat swab samples Confirmed cases based on positive PCR, suspected cases based on symptoms and exposures only, clinically cases based on symptoms, exposures, and CT, asymptomatic cases diagnosis by positive PCR Spectrum of disease: (N = 44,415); mild:
T253 915-936 Sentence denotes 81% (36,160), severe:
T254 937-959 Sentence denotes 14% (6,168), critical:
T255 960-995 Sentence denotes 5% (2,087) Cardiovascular disease:
T256 996-1012 Sentence denotes 10.5%, diabetes:
T257 1013-1047 Sentence denotes 7.3%, chronic respiratory disease:
T258 1048-1067 Sentence denotes 6.3%, hypertension:
T259 1068-1081 Sentence denotes 6.0%, cancer:
T260 1082-1371 Sentence denotes 5.6% About a week 2.3% (1,023 of 44,672 confirmed cases), 14.8% aged >80 years (208 of 1,408), 8.0% aged 70–79 years (312 of 3,918) 49.0% in critical cases (1,023 of 2,087) Next step: to help “buy time” for more diagnostic and therapeutic research before COVID‐19 becomes too widespread
T261 1372-1564 Sentence denotes Tian et al. (2020), China Retrospective study/Beijing Emergency Medical Service 262/47.5/48.5% male Real‐time RT‐PCR Respiratory specimens COVID‐19 infected patients/residents of Beijing:
T262 1565-1604 Sentence denotes 92 (73.3%), patients had been to Wuhan:
T263 1605-1652 Sentence denotes 50 (26.0%), close contact with confirmed cases:
T264 1653-1685 Sentence denotes 116 (60.4%), no contact history:
T265 1686-1725 Sentence denotes 21 (10.9%) Spectrum of disease: sever:
T266 1726-1745 Sentence denotes 46 (17.6%); common:
T267 1746-1765 Sentence denotes 216; (82.4%); mild:
T268 1766-1792 Sentence denotes 192 (73.3%); nonpneumonia:
T269 1793-1977 Sentence denotes 11 (4.2%); asymptomatic:13 (5.0%) Fever (82.1%), cough (45.8%), fatigue (26.3%), dyspnea (6.9%), headache (6.5%)/pulmonary infection, chronic cardiovascular disease and heart failure:
T270 1978-2031 Sentence denotes 1, pulmonary infection and multiple chronic diseases:
T271 2032-2046 Sentence denotes 1 Incubation:
T272 2047-2089 Sentence denotes 6.7 days, illness onset to visit hospital:
T273 2090-2118 Sentence denotes 4.5 days 3 (0.9%) Results:
T274 2119-2173 Sentence denotes As of February 10, 45 (17.2%) patients have discharged
T275 2174-2313 Sentence denotes For COVID‐19 control: first step is prevent transmission at early stage, next steps is early isolation and quarantine of suspected subjects
T276 2314-2673 Sentence denotes Wang et al. (2020), China Retrospective cohort/Xi'an Jiaotong University First Affiliated Hospital, Nanchang University First Hospital and Xi'an No.8 Hospital of Xi'an Medical College 99 CT, artificial intelligence, inception migration‐learning model – Pathogen‐confirmed COVID‐19 patients Spectrum of disease: typical viral pneumonia or negative group:
T277 2674-2727 Sentence denotes 55, confirmed nucleic acid testing or positive group:
T278 2728-2731 Sentence denotes 44.
T279 2732-2761 Sentence denotes CT (453 CT images): negative:
T280 2762-2776 Sentence denotes 258, positive:
T281 2777-2824 Sentence denotes 195 Viral pneumonia symptoms – – Screening:
T282 2825-2859 Sentence denotes The internal validation; accuracy:
T283 2860-2879 Sentence denotes 82·9%, specificity:
T284 2880-2899 Sentence denotes 80·5%, sensitivity:
T285 2900-2903 Sentence denotes 84%
T286 2904-2935 Sentence denotes The external testing; accuracy:
T287 2936-2955 Sentence denotes 73·1%, specificity:
T288 2956-2973 Sentence denotes 67%, sensitivity:
T289 2974-2977 Sentence denotes 74%
T290 2978-3053 Sentence denotes Algorithm prediction: a rate of 2 s per case on the graphic processing unit
T291 3054-3174 Sentence denotes Interpretation: the early diagnosis through fast, accurate, safe and noninvasive methods is crucial for control of virus
T292 3175-3480 Sentence denotes Yan et al. (2020), China Retrospective study/Tongji Hospital 375, 58.83, 58.7% males CT, machine learning model (a supervised XGBoost classifier) – Validated or suspected COVID‐19 patient/Wuhan residents (37.9%), familial cluster (6.4%), health workers (1.9%) Spectrum of disease: critical patients:
T293 3481-3541 Sentence denotes 46.1%, severe cases: RR ≥ 30bpm or SPO2 ≤93% on rest Fever:
T294 3542-3555 Sentence denotes 49.9%, cough:
T295 3556-3597 Sentence denotes 13.9%, fatigue 3.7%, dyspnea 2.1%, shock:
T296 3598-3605 Sentence denotes 2 174
T297 3606-3821 Sentence denotes 16 + 1 Interpretation: the three indices‐based prognostic prediction model might predict themortality risk, recognition of critical cases, help to early identification, on time intervention, reducing mortality rate
T298 3822-4082 Sentence denotes Shi et al. (2020), China Retrospective/hospitals in Wuhan 81, 49–5, 42 (52%) men and 39 (48%) women Next‐generation sequencing or RT‐PCR, serial chest CT Throat swab specimens Confirmed COVID‐19 pneumonia patients/direct exposure to Huanan seafood market:
T299 4083-4113 Sentence denotes 31 (38%), health‐care workers:
T300 4114-4142 Sentence denotes 15 (19%), familial clusters:
T301 4143-4183 Sentence denotes 7 (9%), any obvious history of exposure:
T302 4184-4253 Sentence denotes 28 (35%) Spectrum of disease: mean number of involved lung segments:
T303 4254-4325 Sentence denotes 10.5 (SD 6.4): group 1: subclinical patients (CT before symptom onset):
T304 4326-4449 Sentence denotes 2.8 (3.3), group 2: ≤1 week after symptom onset/11.1 (5.4), group 3: >1–2 weeks/13.0 (5.7), group 4: >2–3 weeks/12.1 (5.9).
T305 4450-4453 Sentence denotes CT:
T306 4454-4458 Sentence denotes ALL:
T307 4459-4481 Sentence denotes bilateral abnormality:
T308 4482-4539 Sentence denotes 64 [79%], peripheral 44 [54%], Ill‐defined 66 [81%], GGO:
T309 4540-4589 Sentence denotes 53 [65%], mainly involving the right lower lobes:
T310 4590-4607 Sentence denotes 225 [27%] of 849.
T311 4608-4635 Sentence denotes Group 1 (n=15): unilateral:
T312 4636-4667 Sentence denotes 9 [60%]/multifocal 8 [53%]/GGO:
T313 4668-4820 Sentence denotes 14 [93%]; Group 2 (n = 21): bilateral 19 [90%]/diffuse 11 [52%]/GGO predominance 17 [81%]; Group 3 (n = 30): GGO 17 [57%], consolidation/mixed patterns:
T314 4821-4876 Sentence denotes 12 [40%]; Group 4 (n=15): consolidation/mixed patterns:
T315 4877-4885 Sentence denotes 8 [53%].
T316 4886-4892 Sentence denotes Blood:
T317 4893-4900 Sentence denotes Group1:
T318 4901-4926 Sentence denotes Lower CRP and AST Fever:
T319 4927-4947 Sentence denotes 59 [73%], dry cough:
T320 4948-4978 Sentence denotes 48 [59%] nonspecific symptoms:
T321 4979-4989 Sentence denotes dizziness:
T322 4990-5007 Sentence denotes 2 [2%], diarrhea:
T323 5008-5025 Sentence denotes 3 [4%], vomiting:
T324 5026-5043 Sentence denotes 4 [5%], headache:
T325 5044-5073 Sentence denotes 5 [6%], generalised weakness:
T326 5074-5122 Sentence denotes 7 [9%]/chronic pulmonary disease (tuberculosis):
T327 5123-5130 Sentence denotes 1, T2D:
T328 5131-5185 Sentence denotes 1, hypertension/cardiovascular/erebrovascular disease:
T329 5186-5288 Sentence denotes 1 Symptom onset and discharge of 23–2 days 3 (4%) By February 8, 2020, 62 (77%) patients discharged
T330 5289-5497 Sentence denotes Interpretation: COVID‐19 pneumonia include CT abnormalities that rapidly progress from focal unilateral to diffuse bilateral GGO coexisted with consolidations within 1–3 weeks (even in asymptomatic patients).
T331 5498-5571 Sentence denotes Early diagnosis through combined CT with clinical and laboratory findings
T332 5572-5661 Sentence denotes Bai et al. (2020), China Case study/The Fifth People's Hospital of Anyang 6, Patient 1:
T333 5662-5971 Sentence denotes 20‐year‐old woman, patients 2–6: four women 42–57 years old CT, RT‐PCR Nasopharyngeal swabs Patient 1: met with Patients 2 and 3, and accompanied five relatives (Patients 2–6), Patients 2–6: no visited Wuhan or been in contact with any other people traveled to Wuhan Spectrum of disease: severe pneumonia:
T334 5972-5992 Sentence denotes 2, moderate: others.
T335 5993-6085 Sentence denotes A familial cluster of five patients with respiratory symptoms, 1 asymptomatic family member.
T336 6086-6092 Sentence denotes Blood:
T337 6093-6153 Sentence denotes all symptomatic patients: increased CRP, reduced lymphocyte.
T338 6154-6239 Sentence denotes CT: multifocal GGO: in all symptomatic patients, subsegmental consolidation/fibrosis:
T339 6240-6242 Sentence denotes 1.
T340 6243-6328 Sentence denotes Patient 1: normal CT, CRP and lymphocyte count, RT‐PCR: negative, positive, negative.
T341 6329-6342 Sentence denotes Patients 2–6:
T342 6343-6362 Sentence denotes COVID‐19 confirmed.
T343 6363-6534 Sentence denotes PCR: positive for patients 2–6 within 1 day Fever: patients 2–6 19 days for patient 1 – Transmission: COVID‐19 transmission could transmit by an asymptomatic carrier S
T344 6535-6848 Sentence denotes Ai et al. (2020), China Cohort/Tangji hospital of Tongji Medical College Huazhong University of Science and Technology, Wuhan, Hubei 1,014/51 ± 15/46% man Laboratory test, chest CT (7 day interval), RT‐PCR (Taq man one step): multiple assays (3 day interval) Throat swab Suspected of nCoV/China Positive CT:
T345 6849-6882 Sentence denotes 88% (888/1,014), positive RT‐PCR:
T346 6883-6899 Sentence denotes 59% (601/1,014).
T347 6900-6943 Sentence denotes Sensitivity of CT based on positive RT‐PCR:
T348 6944-6973 Sentence denotes 97% (95%CI, 95–98%, 580/601).
T349 6974-7002 Sentence denotes Negative RT‐PCR/positive CT:
T350 7003-7017 Sentence denotes 75% (308/413).
T351 7018-7098 Sentence denotes Initial positive CT consistent with COVID‐19 before the initial positive RT‐PCR:
T352 7099-7106 Sentence denotes 60–93%.
T353 7107-7170 Sentence denotes Improvement in follow‐up CT before the RT‐PCR turning negative:
T354 7171-7192 Sentence denotes 42% (24/57), CT: GGO:
T355 7193-7223 Sentence denotes 46% [409/888], consolidations:
T356 7224-7258 Sentence denotes 50% [447/888], bilateral findings:
T357 7259-7311 Sentence denotes 90% [801/888] Fever, dry cough Initial + to − PCR:
T358 7312-7327 Sentence denotes 5.1 ± 1.5 days,
T359 7328-7347 Sentence denotes Initial − to + PCR:
T360 7348-7497 Sentence denotes 6.9 ± 2.3 days – Diagnosis: chest CT, as a highly sensitive method, could be considered as a primary tool for infection diagnosis in epidemic areas
T361 7498-7598 Sentence denotes Chen et al. (2020), China General Hospital of Central Theater Command, PLA 48/age; critically ill:
T362 7599-7616 Sentence denotes 79.6 ± 12, sever:
T363 7617-7633 Sentence denotes 63.9 ± 15, mild:
T364 7634-7806 Sentence denotes 45.8 ± 14/31 males (77.1%) and 17 females (22.9%) Real‐time RT‐PCR, CT, GLMs analysis Serum, throat‐swab specimens Laboratory confirmed cases Spectrum of disease: mild:
T365 7807-7864 Sentence denotes 21 (43.7%), severe 10 (20.8%), critically ill 17 (35.4%).
T366 7865-7985 Sentence denotes Blood: low/lower lymphocytes: severe and critically ill, higher neutrophils: critically ill, higher PCT: critically ill.
T367 7986-8093 Sentence denotes Parameters stand for the organ dysfunction; TnT, AST, ALT, CRE, and BUN: higher in critically ill patients.
T368 8094-8098 Sentence denotes PCR:
T369 8099-8128 Sentence denotes positive RNAaemia: (a) serum:
T370 8129-8174 Sentence denotes 5 (10.4%) of critically ill, (b) throat‐swab:
T371 8175-8187 Sentence denotes 48 positive.
T372 8188-8205 Sentence denotes IL‐6: value ≥100:
T373 8206-8361 Sentence denotes 35.3% in critically ill, 10‐folds higher IL‐6 (cytokine storm): critically ill, RNAaemia positive: IL‐6 ≥100 (R = 0.902) Mild: fever, respiratory symptoms
T374 8362-8469 Sentence denotes Severe: shortness of breath, RR ≥ 30 times/min, oxygen saturation (resting state) ≤93%, PaO2/FiO2 ≤300 mmHg
T375 8470-8546 Sentence denotes Critically ill: respiratory failure, shock, multiple organ failure/diabetes:
T376 8547-8570 Sentence denotes 12 [25%], hypertension:
T377 8571-8597 Sentence denotes 23 [49.7%], heart disease:
T378 8598-8632 Sentence denotes 8 [16.7%], mixed fungal infection:
T379 8633-8742 Sentence denotes 27.1%, bacterial infection: (2.1%) – 3 Diagnosis; RNAaemia positive test confirmed critically ill patients
T380 8743-8854 Sentence denotes Prognosis: strong association between RNAaemia with cytokine storm can be applied to predict the poor prognosis
T381 8855-8950 Sentence denotes Therapeutic approach: in critically patients, IL‐6 should be considered as a therapeutic target
T382 8951-9136 Sentence denotes Fan et al. (2020), China Retrospective cohort study/three tertiary hospitals of Wenzhou 149/45.11 ± 13.35/81 (54.4%) males Laboratory test, PCR, CT Blood RT‐PCR confirmed patients:
T383 9137-9174 Sentence denotes Hubei travel/residence history: N=85,
T384 9175-9254 Sentence denotes contact with people of Hubei: N=49, no traceable exposure history: N=15 Blood:
T385 9255-9283 Sentence denotes decreased oxygen saturation:
T386 9284-9305 Sentence denotes 14(9.4%), leukopenia:
T387 9306-9330 Sentence denotes 33 (24.2%), lymphopenia:
T388 9331-9357 Sentence denotes 53 (35.6%), low platelets:
T389 9358-9383 Sentence denotes 20 (13.4%), elevated CRP:
T390 9384-9432 Sentence denotes 82 (55.0%), ALT/AST/CK and D‐dimer: less common.
T391 9433-9465 Sentence denotes CT: most involved lung segments:
T392 9466-9477 Sentence denotes 6 and, GGO:
T393 9478-9506 Sentence denotes 287 segments, mixed opacity:
T394 9507-9535 Sentence denotes 637 segments, consolidation:
T395 9536-9739 Sentence denotes 170 segments, lesions: more in the peripheral lung with a patchy form, normal CT on admission: N=17, negative CT: N=12, no significant difference between patients with or without exposure history Fever:
T396 9740-9755 Sentence denotes 114/149, 76.5%,
T397 9756-9762 Sentence denotes Cough:
T398 9763-9777 Sentence denotes 87/149, 58.4%,
T399 9778-9792 Sentence denotes Expectoration:
T400 9793-9862 Sentence denotes 4 8/149, 32.2%, mild infection/cerebrovascular or digestive diseases:
T401 9863-9887 Sentence denotes 52 (34.9%) Negative CT:
T402 9888-9986 Sentence denotes 10 days, 6.8 (5.0) days 0 (0.0%) Diagnosis: a normal CT cannot exclude the diagnosis of COVID‐19
T403 9987-10181 Sentence denotes Fan et al. (2020), China Retrospective, case series/Chongqing University Three Gorges Hospital 51/45/32 (62.7%) men Laboratory test, CT Blood Confirmed COVID‐19: patients had been to Wuhan:
T404 10182-10231 Sentence denotes 43 (84.3%), contact history of COVID‐19 patients:
T405 10232-10297 Sentence denotes 4 (7.7%), no clear contact history:4 (7.7%) Spectrum of disease:
T406 10298-10342 Sentence denotes nonsevere patients: n = 44, severe patients:
T407 10343-10352 Sentence denotes 7 (13.7%)
T408 10353-10372 Sentence denotes Blood: lymphopenia:
T409 10373-10398 Sentence denotes 26 (51.0%), elevated CRP:
T410 10399-10410 Sentence denotes 32 (62.7%).
T411 10411-10414 Sentence denotes CT:
T412 10415-10419 Sentence denotes GGO:
T413 10420-10465 Sentence denotes 41 [80.4%], local consolidation of pneumonia:
T414 10466-10497 Sentence denotes 17 [33.3%], pleural thickening:
T415 10498-10543 Sentence denotes 20 (39.2%), small amount of pleural effusion:
T416 10544-10577 Sentence denotes 7 (13.7%), streak shadow of lung:
T417 10578-10619 Sentence denotes 8 (15.7%), multiple solid nodular shadow:
T418 10620-10646 Sentence denotes 4 (7.8%), air bronchogram:
T419 10647-10677 Sentence denotes 2 (3.9%), single lobe lesions:
T420 10678-10710 Sentence denotes 2 (3.9%), multiple lobe lesions:
T421 10711-10729 Sentence denotes 49 (96.1%) Fever:
T422 10730-10748 Sentence denotes 43 [84.3%], cough:
T423 10749-10790 Sentence denotes 38 [74.5%], dry cough with expectoration:
T424 10791-10811 Sentence denotes 16 (31.4%), fatigue:
T425 10812-10833 Sentence denotes 22 [43.1%], asthenia:
T426 10834-10854 Sentence denotes 22 (43.1%), dyspnea:
T427 10855-10861 Sentence denotes 11/DM:
T428 10862-10894 Sentence denotes 4 [57.1%] 2–5 days 1 Therapy:
T429 10895-10909 Sentence denotes TCM decoction:
T430 10910-10961 Sentence denotes 28 [54.9%], aerosol inhalation of recombinant human
T431 10962-10978 Sentence denotes Interferon a‐1b:
T432 10979-11010 Sentence denotes 51 (100%), Lopinavir/Ritonavir:
T433 11011-11054 Sentence denotes 51 [100%], Bacillus licheniformis capsules:
T434 11055-11092 Sentence denotes 44 [86.3%], glucocorticoid treatment:
T435 11093-11103 Sentence denotes 10 (19.6%)
T436 11104-11147 Sentence denotes Older patients with server COVID‐19 (N = 7)
T437 11148-11169 Sentence denotes Antibiotic treatment:
T438 11170-11197 Sentence denotes 7 [100%], nutritional diet:
T439 11198-11232 Sentence denotes 6 [85.7%), human albumin infusion:
T440 11233-11269 Sentence denotes 4 (57.1%), immunoglobulin treatment:
T441 11270-11304 Sentence denotes 4 (57.1%), mechanical ventilation:
T442 11305-11314 Sentence denotes 6 [85.7%]
T443 11315-11526 Sentence denotes Results and interpretation: discharged 50 patients after 12 days, without the common clinical symptoms, with the significant increased lymphocyte (p = .008) and significant decreased CRP significantly (p < .001)
T444 11527-11774 Sentence denotes Fan et al. (2020), China Retrospective/Shanghai Public Health Clinical Center 148/50.5/49.3% females and 50.7% males Laboratory test, RT‐PCR and CT scanning Sera Confirmed SARS‐CoV‐2‐infected patients/a history of related epidemiology Blood:
T445 11775-11812 Sentence denotes elevated LDH, AST, ALT, GGT, TB, ALP:
T446 11813-12090 Sentence denotes 35.1%, 21.6%, 18.2%, 17.6%, 6.1%, 4.1% in all patients; lower CD4+ and CD8+ T cells: (62.67%)/(56.1%) patients with abnormal liver function received more treatment compared with normal liver function (25%) (p = .009) Fever: (70.1%), cough: (45.3%), expectoration at admission:
T447 12091-12099 Sentence denotes (26.7%),
T448 12100-12138 Sentence denotes Abnormal liver functions at admission:
T449 12139-12265 Sentence denotes 75 patients (50.7%) with moderate‐high degree fever (44%) in males,/chronic hepatitis B or C: N = 8 5 days (3–7) 1 Therapy:
T450 12266-12403 Sentence denotes Antibiotics (Levofloxacin, Meropenem, Moxifloxacin, Cephalosporin), interferon, antiviral drugs (Arbidol, Lopinavir/ritonavir, Dnrunavir)
T451 12404-12431 Sentence denotes Results and interpretation:
T452 12432-12474 Sentence denotes all patients discharged from the hospital.
T453 12475-12577 Sentence denotes Lopinavir/Ritonavir treatment can significantly alleviate the SARS‐CoV‐2‐induced liver function damage
T454 12578-12966 Sentence denotes Chen et al. (2020) China Retrospective/Zhongnan Hospital of Wuhan University, Wuhan 9/26–34/female Clinical records, laboratory results, CT scans Amniotic fluid, cord blood, and neonatal throat swab, breastmilk samples Pregnant women with laboratory‐confirmed COVID‐19 pneumonia and caesarean section in their third trimester/a history of epidemiological exposure to COVID‐19 Blood:
T455 12967-13080 Sentence denotes lymphopenia: N = 5, elevated CRP: N = 6, increased ALT and AST: N = 3, normal WBC count: N = 7, lower WBC: N = 1.
T456 13081-13156 Sentence denotes Nine mothers: none developed severe COVID‐19 pneumonia or dying as of Feb4.
T457 13157-13169 Sentence denotes Six mothers:
T458 13170-13258 Sentence denotes amniotic fluid, cord blood, neonatal throat swab, and breastmilk: negative for COVID‐19.
T459 13259-13275 Sentence denotes Nine livebirths:
T460 13276-13360 Sentence denotes with 1‐min Apgar score of 8–9 and a 5‐min Apgar score of 9–10, No neonatal asphyxia.
T461 13361-13364 Sentence denotes CT:
T462 13365-13501 Sentence denotes multiple patchy ground‐glass shadows: N=8 Fever: N = 7, cough N = 4, myalgia N = 3, sore throat: N = 2, malaise: N = 2, fetal distress:
T463 13502-13533 Sentence denotes N = 2/gestational hypertension:
T464 13534-13717 Sentence denotes N = 1, pre‐eclampsia: N = 1, influenza virus infection: N = 1 Short None Therapy: oxygen support (nasal cannula) and empirical antibiotic treatment: N = 9, antiviral therapy: N = 6
T465 13718-13822 Sentence denotes Interpretation: no evidence for intrauterine infection caused by vertical transmission in late pregnancy
T466 13823-13984 Sentence denotes Lim et al. (2020), Korea Public health center, Myongji Hospital 1/54/male PCR, CT Throat swab, sputum A Korean man living in Wuhan China/Virus transmission;
T467 13985-14084 Sentence denotes from index patient Patient A to Patients B, C, D@@ Spectrum of disease: mild respiratory symptoms.
T468 14085-14088 Sentence denotes CT:
T469 14089-14197 Sentence denotes small consolidation in right upper lobe, GGO in both lower lobes Chills, muscle pain 5–7 days – Therapy:
T470 14198-14217 Sentence denotes Lopinavir/Ritonavir
T471 14218-14245 Sentence denotes Results and interpretation:
T472 14246-14403 Sentence denotes significant decrease in β‐coronavirus viral loads due to the natural course of the healing process rather than administration of Lopinavir/Ritonavir, or both
T473 14404-14718 Sentence denotes Wu et al. (2020), China Retrospective/three Grade IIIA hospitals of Jiangsu 80/46.1/41 female (51.25%) Laboratory testing, real time RT‐PCR, CT Throat swab and/or nose swab, blood Confirmed COVID‐19 patients/with a history of epidemic in Wuhan and without contact with the seafood market Spectrum of disease:
T474 14719-14724 Sentence denotes mild:
T475 14725-14747 Sentence denotes 28 (35.00%), moderate:
T476 14748-14768 Sentence denotes 49 (61.25%), severe:
T477 14769-14800 Sentence denotes 3 (3.75%), critically ill: none
T478 14801-14812 Sentence denotes Laboratory:
T479 14813-14823 Sentence denotes lower WBC:
T480 14824-14853 Sentence denotes 36 (45.00%), lymphocytopenia:
T481 14854-14883 Sentence denotes 26 (32.50%), lower platelets:
T482 14884-14906 Sentence denotes 11 (13.75%), high CRP:
T483 14907-14929 Sentence denotes 62 (77.50%), high ESR:
T484 14930-14956 Sentence denotes 59 (73.75%), elevated PCT:
T485 14957-14967 Sentence denotes 1 (1.25%).
T486 14968-14983 Sentence denotes Liver function:
T487 14984-15002 Sentence denotes increased ALT/AST:
T488 15003-15028 Sentence denotes 3 (3.75%), lower albumin:
T489 15029-15039 Sentence denotes 2 (2.50%).
T490 15040-15095 Sentence denotes Abnormal myocardial enzyme spectrum and increase of CK:
T491 15096-15108 Sentence denotes 18 (22.50%).
T492 15109-15123 Sentence denotes Increased LDH:
T493 15124-15136 Sentence denotes 17 (21.25%).
T494 15137-15159 Sentence denotes Renal function damage:
T495 15160-15170 Sentence denotes 2 (2.50%).
T496 15171-15201 Sentence denotes Serious renal function damage:
T497 15202-15204 Sentence denotes 1.
T498 15205-15219 Sentence denotes Hyperglycemia:
T499 15220-15232 Sentence denotes 19 (23.17%).
T500 15233-15251 Sentence denotes Increased D‐dimer:
T501 15252-15262 Sentence denotes 3 (3.75%).
T502 15263-15342 Sentence denotes 9 kinds of respiratory pathogens and influenza A/B nucleic acids: all patients.
T503 15343-15356 Sentence denotes CT: abnormal:
T504 15357-15390 Sentence denotes 55 (68.75%), bilateral pneumonia:
T505 15391-15425 Sentence denotes 36 (45.00%), unilateral pneumonia:
T506 15426-15446 Sentence denotes 19 (23.75%), normal:
T507 15447-15459 Sentence denotes 25 (31.25%).
T508 15460-15499 Sentence denotes Organ damage: acute respiratory injury:
T509 15500-15526 Sentence denotes 10 (12.50%), renal injury:
T510 15527-15544 Sentence denotes 2 (2.50%) Fever:
T511 15545-15564 Sentence denotes 63 (78.75%), cough:
T512 15565-15598 Sentence denotes 51 (63.75%), shortness of breath:
T513 15599-15624 Sentence denotes 30 (37.50%), muscle ache:
T514 15625-15647 Sentence denotes 18 (22.50%), headache:
T515 15648-15678 Sentence denotes 13 (16.25%) liver dysfunction:
T516 15679-15797 Sentence denotes 3 (3.75%)/cardiovascular/cerebrovascular, endocrine, digestive, respiratory, malignancies and nervous system diseases:
T517 15798-15833 Sentence denotes 38 (47.50%) 8.0 Not now Therapy:
T518 15834-15847 Sentence denotes all patients:
T519 15848-15940 Sentence denotes single antibiotic mainly Moxifloxacin and Ribavirin antiviral therapy, 12 (14.63%) patients:
T520 15941-16021 Sentence denotes methylprednisolone sodium succinate or methylprednisolone, 35 (43.75%) patients:
T521 16022-16086 Sentence denotes noninvasive ventilator, 1 patient: hemodialysis, 3 patients: TCM
T522 16087-16102 Sentence denotes Interpretation:
T523 16103-16141 Sentence denotes 21 cases discharged from the hospital:
T524 16142-16273 Sentence denotes With no obvious gender susceptivity, lower proportion of liver dysfunction, abnormal CT and higher frequency nucleic acid detection
T525 16274-16490 Sentence denotes Li et al. (2020), China Retrospective study/hospital in Wenzhou 175/46/92 women, 83/men Real‐time PCR, CT Respiratory tract samples or blood samples Confirmed COVID‐19/a history of exposure to the epidemic area:
T526 16491-16530 Sentence denotes 57 (33%) patients Spectrum of disease:
T527 16531-16540 Sentence denotes COVID‐19:
T528 16541-16822 Sentence denotes mild: mild clinical manifestations, no pneumonia; moderate: respiratory symptoms, mild pneumonia, severe (37): pneumonia, ARDS with RR >30 times/min, oxygen saturation <93%; critical (3): pneumonia, shock, respiratory failure, and failures in other organs, nearly all patients: GGO
T529 16823-16826 Sentence denotes K+:
T530 16827-16846 Sentence denotes severe hypokalemia:
T531 16847-16997 Sentence denotes 39 (higher body temperature, higher heart rate and RR, higher prevalence of dyspnea or tachypnea (p < .05)), hypokalemia 69, normokalemia patients 67.
T532 16998-17189 Sentence denotes Correlations: severity of hypokalemia with body temperature, CK, CK‐MB, LDH, and CRP (p < .01), 93% of severe/critically ill patients showed hypokalemia Cough, fever, pneumonia/hypertension:
T533 17190-17203 Sentence denotes 28, diabetes:
T534 17204-17243 Sentence denotes 12, other conditions:31 6 – Therapy:
T535 17244-17274 Sentence denotes 1 severe hypokalemia patients;
T536 17275-17331 Sentence denotes 3 g/day K+, 34 (SD = 4) g potassium during hospital stay
T537 17332-17406 Sentence denotes Good response of patients to K+ supplements when they inclined to recovery
T538 17407-17469 Sentence denotes Interpretation: hypokalemia is prevailing in COVID‐19 patients
T539 17470-17706 Sentence denotes Lan et al. (2020), China Case study/Zhongnan Hospital of Wuhan University, Wuhan 4, 30–36 years, 2 male RT‐PCR, thin‐section CT Throat swabs Medical personnel quarantined at home with COVID‐19 Spectrum of disease: mild to moderate
T540 17707-17806 Sentence denotes Results: (at admission); PCR positive: for all CT positive: for all GGO, or mixed GGO/consolidation
T541 17807-17940 Sentence denotes (after therapy); 2 consecutive negative RT‐PCR: all (after discharge); repeated RT‐PCR 5–13 days later: all positive Fever:3, cough:
T542 17941-17949 Sentence denotes 3, both:
T543 17950-17979 Sentence denotes 3 Symptom onset to recovery:
T544 17980-18058 Sentence denotes 12–32 days – Therapy: antiviral treatment (75 mg of oseltamivir every 12 hr)
T545 18059-18107 Sentence denotes Resolved clinical symptoms and CT abnormalities:
T546 18108-18109 Sentence denotes 3
T547 18110-18134 Sentence denotes Delicate patches of GGO:
T548 18135-18136 Sentence denotes 1
T549 18137-18233 Sentence denotes Interpretation: possibility of at least a proportion of recovered patients act as virus carriers
T550 18234-18480 Sentence denotes Li et al. (2020), China Retrospective study/Sino‐French New Town area Tongji Hospital 47, 62, 28 (59.6%) men Real‐time RT‐PCR Throat‐swab specimens, sputum or endotracheal aspirates Patients with severe COVID‐19 Spectrum of disease: severe:
T551 18481-18493 Sentence denotes 41 critical:
T552 18494-18525 Sentence denotes 5(17.9%) men and 1 (5.3%) women
T553 18526-18570 Sentence denotes Common: oxygen saturation <93% after routine
T554 18571-18591 Sentence denotes Nasal oxygen supply:
T555 18592-18605 Sentence denotes 3 men/1 woman
T556 18606-18674 Sentence denotes Blood: PCT: higher in men, N‐terminal‐pro brain natriuretic peptide:
T557 18675-18715 Sentence denotes Higher in 16(57.1%) men/5 (26.3%) women,
T558 18716-18746 Sentence denotes Positive influenza A antibody:
T559 18747-18768 Sentence denotes 5 men (17.9%) Fever:
T560 18769-18787 Sentence denotes 34 [72.3%], cough:
T561 18788-18808 Sentence denotes 36 [76.6%], myalgia:
T562 18809-18828 Sentence denotes 5 [10.6%], fatigue:
T563 18829-18853 Sentence denotes 7 [14.9%]/comorbidities:
T564 18854-18865 Sentence denotes 30 (63.8%):
T565 18866-18942 Sentence denotes COPD, hypertension/CVD lower in men – 3.6% in men and 0 in women Therapy:
T566 18943-18993 Sentence denotes antibiotics applied more in the men than the women
T567 18994-19021 Sentence denotes Results and interpretation:
T568 19022-19062 Sentence denotes 4 (21.1%) women/1 man (3.6%) discharged.
T569 19063-19186 Sentence denotes Possibility of sex differences in severe COVID‐19 patients, Men with more complicated clinical condition and worse outcomes
T570 19187-19433 Sentence denotes Han et al. (2020) Case study/People's Hospital in Wuwei A 47‐year‐old man/smoking for 20 years/no alcohol abuse RT‐PCR, CT Nasopharyngeal swab specimens Confirmed SARS‐CoV‐2/returned to Wuwei city on January 18 from Wuhan city by car Blood:
T571 19434-19533 Sentence denotes decreased lymphocytes, increased CRP, slightly elevated fibrinogen, neutrophil, LDH, and fibrinogen
T572 19534-19586 Sentence denotes PCR: positive for expression of RdRPN, N and E genes
T573 19587-19935 Sentence denotes CT: multiple patchy high‐density shadows scattered mainly in the border regions of lungs, solid changes, GGO changes, slightly thickened pleura Fever, cough productive of white phlegm, bosom frowsty, stuffy/runny noses, vertigo, fatigue, chest tightness, nausea, expiratory dyspnea, poor diet, lethargy/hypertension grade 2 and T2D – – Therapy:
T574 19936-19966 Sentence denotes combination therapy including:
T575 19967-20296 Sentence denotes Lopinavir/Ritonavir (800/200 mg daily), methylprednisolone (40 mg daily), recombinant human interferon α‐2b (10 million IU daily), ambroxol hydrochloride (60 mg daily) moxifloxacin hydrochloride (0.4 g daily), high flow humidification oxygen inhalation therapy, treatment of blood glucose, blood pressure, and rehydration therapy
T576 20297-20452 Sentence denotes Results interpretation: the persistent negative results of SARS‐CoV‐2 on days 6 and 7, normal TLC, lung lesions partially absorbed, The patient discharged.
T577 20453-20618 Sentence denotes Laboratory tests like TLC are necessary, CT combined with RT‐PCR is helpful, Lopinavir/Ritonavir are effective after failure of methylprednisolone/interferon alfa‐2b
T578 20619-20776 Sentence denotes Liu et al. (2020), China Retrospective cohort and case study/Zhongnan Hospital of Wuhan University Dawu County People's Hospital 124 patients, 22 patients:
T579 20777-20938 Sentence denotes 12 therapy (mean age 53), 10 control (mean age 58) CT, PCR Serum 124 confirmed COVID‐19 cases, 12 HCOV infected patients Blood: (Study 1) decreased platelet:
T580 20939-20964 Sentence denotes 25 (20.2%), prolonged PT:
T581 20965-20991 Sentence denotes 77 (62.1%), increased FIB:
T582 20992-21026 Sentence denotes 27 (21.8%), and increased D‐dimer:
T583 21027-21037 Sentence denotes 26 (21.0%)
T584 21038-21082 Sentence denotes Spectrum of disease: (study 2) severe cases:
T585 21083-21096 Sentence denotes 6 mild cases:
T586 21097-21114 Sentence denotes 4 critically ill:
T587 21115-21116 Sentence denotes 2
T588 21117-21184 Sentence denotes CT: (study 2) Bilateral pneumonia: all Study 1: hypercoagulability
T589 21185-21260 Sentence denotes Study 2: cough: all shortness of breath: most of them, nausea and vomiting:
T590 21261-21315 Sentence denotes 60.0%/DM, cardiovascular and cerebrovascular diseases:
T591 21316-21381 Sentence denotes 4 patients from the DIP, 5 patients control group – 1 Therapy:
T592 21382-21584 Sentence denotes Dipyridamole (150 mg in three separate doses for 7 consecutive days), antiviral (ribavirin, 0.5 g, Q12hr), corticoid (methylprednisolone sodium succinate, 40 mg, qd), oxygen therapy, nutritional support
T593 21585-21696 Sentence denotes Results and interpretation: significant increase in platelet/lymphocyte, significant decrease in D‐dimer levels
T594 21697-21717 Sentence denotes Discharged patients:
T595 21718-21759 Sentence denotes 50% of severe cases and all 4 mild cases.
T596 21760-21894 Sentence denotes Dipyridamole adjunctive therapy could significantly reduce viral replication, inhibits hypercoagulability and improves immune recovery
T597 21895-22948 Sentence denotes Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; ARDS, acute respiratory distress syndrome; AST, aspartate aminotransferase; BUN, blood urea nitrogen; CK, creatine kinase; CK‐MB, creatine kinase myocardial band; COPD, chronic obstructive pulmonary disease; CRE, serum creatinine; CRP, C‐reactive protein; CT, computed tomography; CVD, cardiovascular disease; DM, diabetes mellitus; DM, diabetes mellitus; ESR, erythrocyte sedimentation rate; FIB, fibrinogen; FiO2, fraction of inspired oxygen; GGO, ground‐glass opacity; GGT, γ‐glutamyltransferase; GLM, Generalized Linear Model; LDH, lactate dehydrogenase; nCoV, novel coronavirus; PaO2, partial pressure of oxygen; PCT, procalcitonin; PT, prothrombin time; RNAaemia, SARS‐CoV‐2 nucleic acid; RR, respiratory rate; RT‐PCR, reverse transcriptase polymerase chain reaction; SpO2, oxygen saturation; T2D, type 2 diabetes; TB, total bilirubin; TCM, traditional Chinese medicine; TCM, traditional Chinese medicine; TLC, total lymphocyte count; TnT, troponin T; WBC, white blood cell.
T598 22949-22972 Sentence denotes John Wiley & Sons, Ltd.
T599 22973-23097 Sentence denotes This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response.
T600 23098-23280 Sentence denotes It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.