LitCovid-sentences  

PMC:7281546 / 54948-57109 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T420 0-60 Sentence denotes PEDV Proteins The Biological Processes Involved References
T421 61-200 Sentence denotes S (S1 and S2) receptor binding and subsequent membrane fusion; replication cycle and propagation; cell apoptosis induction [48,49,50,128]
T422 201-411 Sentence denotes N viral replication, transcription, and assembly; extension of S-phase of cell cycle; endoplasmic reticulum (ER) stress formation; innate immunity antagonist; interaction with host protein NPM1 [44,56,57,129]
T423 412-581 Sentence denotes M virion assembly and virus budding; induction of PEDV neutralizing antibodies; cell growth retardation in S-phase; IFN antagonist with unknown mechanism [62,63,64,65]
T424 582-679 Sentence denotes E virus packaging and budding; stimulation of ER stress and activation of NF-κB pathway [66,67]
T425 680-784 Sentence denotes ORF3 detention of cells at S-phase; facilitating vesicle formation; promoting PEDV replication [69,70]
T426 785-1011 Sentence denotes nsp1 type I IFNs and type III IFN antagonists; inducing the degradation of CBP; suppression of phosphorylation and degradation of IκBα, as well as p65 nuclear translocation; blocking nuclear translocation of IRF1 [65,78,130]
T427 1012-1025 Sentence denotes nsp2 Unknown
T428 1026-1239 Sentence denotes nsp3,4,6 nsp3, 4, and 6 are all involved in viral replication process; nsp3 also acts as a viral deubiquitinase (DUB) that deubiquitinates RIG-I and STING and negatively regulates type I IFN signaling [80,94,99]
T429 1240-1404 Sentence denotes nsp5 3CLpro; processing replicase polyprotein during virus replication; blocking host innate immune responses by cleavage of NF-κB essential modulator (NEMO) [99]
T430 1405-1604 Sentence denotes nsp7–10 Nsp7 is an IFN antagonist; nsp8 inhibits type III IFN response; nsp9 is involved in nucleic acid binding; nsp10 enhances the inhibitory effect of nsp16 on IFN-β production. [65,131,132,133]
T431 1605-1653 Sentence denotes nsp12 encoding a RdRp; viral replication [134]
T432 1654-1725 Sentence denotes nsp13 a NTPase/helicase that is essential for viral replication [111]
T433 1726-1950 Sentence denotes nsp14 N-7-MTase; catalyzing N7-methylation of Gppp-RNA to form a cap-0 structure; 3′-5′ exoribonuclease activity involves in a replicative mismatch repair system during RNA synthesis; IFN antagonist [42,65,112,113,119,133]
T434 1951-2059 Sentence denotes nsp15 EndoU; IFN antagonist; inhibition of the type I IFN and the type III IFN responses [114,115,116,135]
T435 2060-2161 Sentence denotes nsp16 2′-O-MTase that catalyzes methylation of the 5’ cap; IFN antagonist [112,123,124,125,126,132]