LitCovid-sentences  

PMC:7281546 / 51016-52413 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T383 0-2 Sentence denotes 5.
T384 3-14 Sentence denotes Conclusions
T385 15-161 Sentence denotes PEDV has caused epidemic and endemic infections in pig populations in many countries and has become a major economic threat to the swine industry.
T386 162-370 Sentence denotes Previous studies have identified viral factors that target key signaling molecules in the RLRs’ pathways, as well as viral factors that target the downstream signaling pathways responsible for ISGs induction.
T387 371-486 Sentence denotes Of the 23 PEDV-encoded proteins, at least 10 viral proteins have been identified as type I IFN antagonists [65,78].
T388 487-637 Sentence denotes The mechanisms utilized by PEDV nsp1, PLP2, nsp5, and N protein to antagonize type I IFN production have been clarified (Figure 3, [58,65,78,80,129]).
T389 638-751 Sentence denotes However, the specific mechanisms of other viral proteins to inhibit type I IFN production remain largely unknown.
T390 752-832 Sentence denotes At present, 11 PEDV proteins have been identified as type III IFNs’ antagonists.
T391 833-1018 Sentence denotes The suppression of type III IFN signaling by N protein, nsp1, as well as nsp15, has been reported, while the mechanisms utilized by these viral proteins need to be further investigated.
T392 1019-1209 Sentence denotes In addition, the CoVs replication cycle may induce the changes of ER stress, cell apoptosis, autophagy pathways, which contain intricate virus-host interactions and cross-talk relationships.
T393 1210-1312 Sentence denotes Thus, more researches for PEDV are needed to truly reflect viral evasions from innate immune defenses.
T394 1313-1397 Sentence denotes The findings of PEDV-host interactions will help prevent and control PEDV spreading.