LitCovid-sentences  

PMC:7281546 / 38457-40562 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T275 0-92 Sentence denotes CoV nsp5 is called 3C-like protease (3CLpro), that resembles the 3Cpro of other RNA viruses.
T276 93-218 Sentence denotes For CoV, the polyprotein precursors (pp1a and pp1b) are mainly processed to generate mature nonstructural proteins by 3CLpro.
T277 219-406 Sentence denotes To date, the 3CLpro of CoVs, including PEDV and PDCoV, have been confirmed to antagonize type I IFN production by the cleavage of NF-κB essential modulator (NEMO) and STAT2 [100,207,208].
T278 407-489 Sentence denotes NEMO is essential for RNA virus-induced activation of NF-κB, IRF3, and IRF7 [209].
T279 490-600 Sentence denotes NEMO is required for MAVS-induced IKKα/β activation and is also crucial for the activation of TBK1/IKKε [149].
T280 601-695 Sentence denotes To establish successful infections, PEDV targets NEMO to subvert host innate immune responses.
T281 696-827 Sentence denotes PEDV nsp5 significantly inhibits Sendai virus (SeV)-induced IFN-β synthesis and the process depends on its protease activity [100].
T282 828-931 Sentence denotes Further experiments show that PEDV nsp5 inhibits RIG-I/MDA5 signaling and targets the upstream of TBK1.
T283 932-1017 Sentence denotes The cleavage of NEMO by nsp5 is identified as responsible for this inhibitive effect.
T284 1018-1112 Sentence denotes The PEDV nsp5-mediated cleavage of NEMO efficiently blocks NEMO-mediated downstream signaling.
T285 1113-1187 Sentence denotes The cleavage site within NEMO that is grasped by nsp5 has been determined.
T286 1188-1355 Sentence denotes Of these reported immune evasion strategies employed by CoVs, the cleavage of innate immune adaptors is a particularly effective manner to disrupt antiviral responses.
T287 1356-1426 Sentence denotes Nsp5 is essential for the life cycle of PEDV and other CoVs [210,211].
T288 1427-1505 Sentence denotes It is a potential target for the development of anti-coronaviral therapeutics.
T289 1506-1678 Sentence denotes Although PEDV nsp5 does not target STAT2 mediated type Ⅰ IFN signaling pathway, PEDV nsp7 has been reported to inhibit the STAT1 and STAT2 induced activation of ISRE [212].
T290 1679-1843 Sentence denotes Nsp7 competes with Karyopherin α (KPNA1), which is an adaptor mediating nuclear translocation of ISGF3, in combination with STAT1, to block ISGF3 nuclear transport.
T291 1844-1937 Sentence denotes However, the expression and phosphorylation of STAT1 and STAT2 are not affected by PEDV nsp7.
T292 1938-2027 Sentence denotes In fact, PEDV infection degrades STAT1, leading to the inhibition of IFN signaling [170].
T293 2028-2105 Sentence denotes Therefore, other PEDV encoded proteins likely target IFNs mediated signaling.