| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T271 |
0-107 |
Sentence |
denotes |
Notably, 3Cpro is a critical IFN antagonistic protein identified in multiple different families of viruses. |
| T272 |
108-389 |
Sentence |
denotes |
The 3Cpro of picornaviruses, including FMDV [199], hepatitis A virus (HAV) [200], enteroviruses (EV71, EV-D68) and coxsackieviruses (CVB3, CV-A16, CV-A6) [201,202,203,204], antagonize innate immune signaling by targeting the critical components of the IFN pathways for proteolysis. |
| T273 |
390-542 |
Sentence |
denotes |
A newly emerged picornavirus, Seneca Valley virus (SVV), has also evolved an effective mechanism to escape host antiviral innate immune using its 3Cpro. |
| T274 |
543-755 |
Sentence |
denotes |
Moreover, 3Cpro cleaves the signaling components (MAVS, TRIF, and TANK) of type I IFN pathway and induces the degradation of the transcription factors IRF3 and IRF7 to constrain host antiviral response [205,206]. |
