LitCovid-sentences  

PMC:7281546 / 34148-36685 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T245 0-358 Sentence denotes The antiviral innate immune signaling pathways are regulated by several posttranslational modifications (PTMs), such as phosphorylation, ubiquitination, glycosylation, NEDDylation and SUMOylation [187], of which ubiquitination is a critical modification to modulate the stability and activity of PRRs and other components of innate immune signaling pathways.
T246 359-514 Sentence denotes During viral infection, a reciprocatory action (occurrence of ubiquitination and deubiquitination) helps maintain the homeostasis of host immune responses.
T247 515-625 Sentence denotes Hence, deubiquitinases (DUBs) are indispensable in the regulation of virus-induced type I IFN signaling [188].
T248 626-737 Sentence denotes Many host DUBs have been reported engaging in the regulation of innate immune signaling pathways [189,190,191].
T249 738-883 Sentence denotes In recent years, a variety of viral DUBs have been discovered to target key components of type I IFN pathway during various RNA virus infections.
T250 884-1127 Sentence denotes For example, foot-and-mouth disease virus leader proteinase (FMDV Lbpro) [192], and porcine reproductive and respiratory syndrome virus nsp2 (PRRSV nsp2) possess ubiquitin-deconjugating activity to deubiquitinate key host components [193,194].
T251 1128-1240 Sentence denotes To counteract host antiviral response, CoVs likely take advantage of DUB activity to break host innate immunity.
T252 1241-1388 Sentence denotes Indeed, the PLPs of mouse hepatitis virus A59 (MHV-A59) [195], SARS [196], and human CoV NL63 have DUB activity and antagonize IFN induction [197].
T253 1389-1517 Sentence denotes PEDV PLP2 has been reported as having a deubiquitinase activity as well, and it can be co-immunoprecipitated by RIG-I and STING.
T254 1518-1687 Sentence denotes As mentioned above, FMDV Lbpro, MHV PLP2 and SARS PLPs all counteract host innate immune response through blocking the ubiquitination of the components of RLRs pathways.
T255 1688-1833 Sentence denotes Similarly, PEDV PLP2 removes the ubiquitinated conjugates from RIG-I and STING by its DUB activity, to negatively regulate type I IFN production.
T256 1834-1997 Sentence denotes PEDV PLP2 probably interacts with RIG-I and STING, which prevents the activation of RIG-I and STING by hindering the recruitment of downstream signaling molecules.
T257 1998-2118 Sentence denotes As expected, the interference with the ubiquitination of RIG-I and STING by PLP2 clearly benefits PEDV replication [80].
T258 2119-2179 Sentence denotes PEDV nsp3 contains two core domains of PLPs (PLPl and PLP2).
T259 2180-2283 Sentence denotes It is determined that PEDV PLP2, but not PLP1, inhibits the IFN-β promoter activation in HEK293T cells.
T260 2284-2355 Sentence denotes The DUB activity of PLP2 is highly dependent on its catalytic activity.
T261 2356-2537 Sentence denotes Three catalytically inactive mutants of PEDV PLP2 (C1729A, H1888A and D1901A) are defective in the deubiquitination of its targets and fail to impair virus-induced IFN-β production.