| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T222 |
0-160 |
Sentence |
denotes |
PEDV nsp1 is the N-terminal cleavage product from polyproteins pp1a and pp1a/b processed by nsp3 and nsp5 [177] and is about 110 amino acids in length [74,178]. |
| T223 |
161-308 |
Sentence |
denotes |
Nsp1 of many α-CoV and β-CoV exhibits both functional conservation and mechanistic diversity in suppressing host gene expression and IFN signaling. |
| T224 |
309-468 |
Sentence |
denotes |
For SARS-CoV, nsp1 triggers the decay and cleavage of host mRNA and inhibits host protein translation, subsequently inhibiting type I IFN production [179,180]. |
| T225 |
469-606 |
Sentence |
denotes |
SARS-CoV nsp1 also blocks the expression of IFN-inducible genes, by restraining the signal transduction during virus infection [181,182]. |
| T226 |
607-697 |
Sentence |
denotes |
The TGEV nsp1 considerably suppresses host protein expression during viral infection [77]. |
| T227 |
698-823 |
Sentence |
denotes |
Structural studies show that the core structure of PEDV nsp1 is highly similar to those of SARS-CoV nsp1 and TGEV nsp1 [183]. |
| T228 |
824-1052 |
Sentence |
denotes |
PEDV nsp1 inhibits host gene expression and three motifs (amino acids 67 to 71, 78 to 85, and 103 to 110) form a stable functional region for inhibition of host protein synthesis, differing considerably from SARS-CoV nsp1 [183]. |
