| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T203 |
0-173 |
Sentence |
denotes |
N protein, as an abundantly produced structural protein within CoV-infected cells, has multiple functions, including virus replication, transcription, and assembly [56,134]. |
| T204 |
174-328 |
Sentence |
denotes |
PEDV N protein has been identified as an IFN antagonist that blocks the expression of IFN-β and ISGs by suppression of the IRF3 and NF-κB activities [58]. |
| T205 |
329-526 |
Sentence |
denotes |
PEDV N protein inhibits the activation of the IFN-β promoter induced by TBK1 and its upstream RIG-I, MDA-5, VISA, and TRAF3, while not affecting the activation of the IFN-β promoter driven by IRF3. |
| T206 |
527-717 |
Sentence |
denotes |
Further experiments confirm that N directly interacts with TBK1 to obstruct the association between TBK1 and IRF3, which inhibits TBK1-induced IRF3 phosphorylation and IFN-β production [58]. |
| T207 |
718-814 |
Sentence |
denotes |
Moreover, the effect of PEDV N protein on type III IFN production has also been evaluated [168]. |
| T208 |
815-1057 |
Sentence |
denotes |
N protein inhibits polyinosinic-polycytidylic acid (poly(I:C))-induced IFN-λ3 production by blocking the nuclear translocation of NF-κB, but does not antagonize the type I or type II IFN expression induced by poly(I:C) in IPEC-J2 cells [168]. |
