LitCovid-sentences  

PMC:7281546 / 14017-15851 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T101 0-384 Sentence denotes CoV nsps play multiple roles in the synthesis or processing of viral RNA, or in virus-host interactions aiming to create an optimal environment for virus replication, such as facilitating viral entry, viral gene expression, RNA synthesis, and virion release. nsp1 is a N-terminal cleavage product of ORF1a polyprotein [71], a 9-kDa protein, that exists only in α-CoVs and β-CoVs [72].
T102 385-489 Sentence denotes The nsp1 of α-CoVs is not very similar to β-CoVs nsp1 with regard to sequence homology and size [73,74].
T103 490-628 Sentence denotes Based on the sequence alignment analysis of the genomes of different CoVs, the viral nsp1 can be regarded as a genus-specific marker [75].
T104 629-711 Sentence denotes Moreover, β-CoVs nsp1 has been widely reported to inhibit host protein expression.
T105 712-784 Sentence denotes However, the biological functions of α-CoVs nsp1 remain largely unknown.
T106 785-934 Sentence denotes Despite the lack of overall sequence similarity, the nsp1 of different CoVs shares a similar function to interfere with host protein expression [76].
T107 935-1028 Sentence denotes These studies suggest the importance of nsp1 in the life cycle of different lineages of CoVs.
T108 1029-1127 Sentence denotes It is shown that TGEV nsp1 inhibits host gene expression and is critical for viral virulence [77].
T109 1128-1250 Sentence denotes PEDV nsp1 induces the degradation of CBP and NF-κB to abate IFN response [78], but the detailed mechanisms remain unclear.
T110 1251-1342 Sentence denotes The sizes and amino acid sequence identity of nsp 2 are variable among different CoVs [76].
T111 1343-1409 Sentence denotes Nsp2 of MHV and SARS-CoV are involved in viral RNA synthesis [79].
T112 1410-1518 Sentence denotes PEDV nsp2 has unknown functions in replication, and may implicate the virus-host interactions and virulence.
T113 1519-1719 Sentence denotes Nsp3 is the largest nsp protein, containing two papain-like protease (PLP1 and PLP2) domains, of which PEDV PLP2 acts as a viral deubiquitinase (DUB), to negatively regulate type I IFN signaling [80].
T114 1720-1834 Sentence denotes CoVs PLPs domains exhibit multiple functions, serving as a viral protease, DUB, as well as an IFN antagonist [81].